CBR4 Activators
Common CBR4 Activators include, but are not limited to Retinoic Acid, all trans CAS 302-79-4, Resveratrol CAS 501-36-0, Quercetin CAS 117-39-5, Curcumin CAS 458-37-7 and N-Acetyl-L-cysteine CAS 616-91-1.
CBR4, known as Carbonyl Reductase 4, is intricately woven into several biological pathways, prominently in metabolism and fatty acyl-CoA biosynthesis. This protein-coding gene has associations with specific diseases, notably Bile Acid Synthesis Defect, Congenital, 5, and Horner's Syndrome. As a mitochondrial NADPH-dependent reductase, CBR4 is specialized for o- and p-quinones, exhibiting a broad spectrum of enzymatic activities. These range from 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity and NADPH binding activity to NADPH dehydrogenase (quinone) activity. Such diverse functionalities highlight its importance in the fatty acid biosynthesis process, glycoside metabolism, and protein tetramerization.
Given the pivotal role of CBR4 in these processes, activators targeting this enzyme could significantly influence cellular metabolic activities. Such activators might aim to enhance the enzyme's substrate affinity, increase its catalytic efficiency, or augment the overall expression of the CBR4 gene. By doing so, they could bolster the metabolic pathways CBR4 is involved in, potentially optimizing the synthesis of fatty acids or improving the efficiency of associated metabolic processes. Moreover, in the context of diseases related to CBR4, these activators could offer a means to modulate the gene's activity, thereby influencing disease progression or manifestation. However, a comprehensive understanding of these interactions, and their potential cellular and systemic implications, is essential to predict the broader biochemical and physiological outcomes of CBR4 activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
May enhance fatty acid synthesis pathways, potentially leading to increased CBR4 expression to handle the redox balance. Retinoic acid is known to influence cellular differentiation and metabolism, which may intersect with the functions of CBR4. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Its antioxidant effects could modulate CBR4 redox activity, possibly leading to increased expression to restore redox homeostasis. Resveratrol is known for its antioxidant properties, which might interact with CBR4's redox activity. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
The antioxidant properties may affect redox balance, potentially inducing CBR4 expression to manage oxidative stress. Quercetin is an antioxidant which might interact with the redox managing functions of CBR4. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Could influence fatty acid metabolism, potentially requiring increased CBR4 expression for redox balance. Curcumin is known to modulate fatty acid metabolism, which is one of the pathways CBR4 is involved in. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
As an antioxidant, it may modulate redox status, possibly requiring increased CBR4 activity and expression. N-Acetylcysteine is a well-known antioxidant that could potentially interact with CBR4's redox balancing functions. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $110.00 $204.00 $435.00 | 9 | |
As a PPARγ agonist, it may modulate fatty acid biosynthesis pathways, potentially leading to increased CBR4 expression to manage redox balance. Troglitazone, as a PPARγ agonist, may modulate fatty acid biosynthesis, a pathway CBR4 is known to be involved in. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
Its antioxidant properties could modulate mitochondrial redox status, possibly inducing CBR4 expression to restore redox homeostasis. Alpha-lipoic acid, due to its antioxidant properties, may interact with the redox managing functions of CBR4. | ||||||
Silymarin group, mixture of isomers | 65666-07-1 | sc-301806 | 50 g | $325.00 | ||
May influence liver metabolism and fatty acid synthesis, potentially leading to increased CBR4 expression to manage redox balance. Silymarin is known to influence liver metabolism and fatty acid synthesis, which could intersect with CBR4 functions. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $73.00 | 2 | |
Its involvement in one-carbon metabolism may have an indirect effect on fatty acid metabolism, potentially affecting CBR4 expression. Folic acid's role in one-carbon metabolism may have downstream effects on pathways CBR4 is involved in. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $71.00 $184.00 | 1 | |
Involved in mitochondrial electron transport, it might modulate redox conditions, possibly inducing CBR4 expression to manage redox balance. Coenzyme Q10 is involved in mitochondrial redox management, which is a function also associated with CBR4. | ||||||