Date published: 2025-12-24

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CatSper3 Inhibitors

CatSper (Cation Channel of Sperm) channels are a family of ion channels found specifically in the tail (or flagellum) of sperm cells. These channels are pivotal in regulating the calcium influx into the sperm, which in turn modulates sperm motility. Proper functioning of these channels is essential for the sperm's ability to navigate through the female reproductive tract and to fertilize the oocyte. CatSper3, a member of the CatSper family, plays a critical role in this calcium-dependent regulation of sperm movement. Inhibitors of CatSper3 act by blocking or modulating the activity of the CatSper3 channel, thereby affecting the calcium entry into the sperm. Given the channel's role in sperm motility, inhibition can result in decreased or altered motility patterns. The molecular structures of these inhibitors vary, and they can be organic or inorganic in nature.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Ibuprofen

15687-27-1sc-200534
sc-200534A
1 g
5 g
$52.00
$86.00
6
(0)

ibuprofen could influence inflammatory responses and cellular pathways that might affect CatSper channels.

Bisphenol A

80-05-7sc-391751
sc-391751A
100 mg
10 g
$300.00
$490.00
5
(0)

Endocrine disruptor which could potentially alter the hormonal balance and thereby the expression of related proteins like CatSper3.

Atrazine

1912-24-9sc-210846
5 g
$165.00
1
(1)

This herbicide can disrupt endocrine systems and might influence the expression of reproductive proteins, including CatSper3.

Glyphosate

1071-83-6sc-211568D
sc-211568
sc-211568A
sc-211568B
sc-211568C
250 mg
1 g
5 g
10 g
25 g
$45.00
$143.00
$408.00
$769.00
$1234.00
4
(0)

As a herbicide, it may impact various biological processes and potentially alter the expression of reproductive proteins.

Ketoconazole

65277-42-1sc-200496
sc-200496A
50 mg
500 mg
$62.00
$260.00
21
(1)

This antifungal agent is known to interfere with steroid synthesis, which could influence the hormonal regulation of proteins like CatSper3.

Vinclozolin

50471-44-8sc-251425
250 mg
$23.00
1
(1)

Acting as an antiandrogen, it might affect male reproductive development and proteins associated with it.

Diethylstilbestrol

56-53-1sc-204720
sc-204720A
sc-204720B
sc-204720C
sc-204720D
1 g
5 g
25 g
50 g
100 g
$70.00
$281.00
$536.00
$1076.00
$2142.00
3
(1)

As a synthetic estrogen, it may disrupt normal hormonal balance, potentially influencing the expression of CatSper channels.

Progesterone

57-83-0sc-296138A
sc-296138
sc-296138B
1 g
5 g
50 g
$20.00
$51.00
$292.00
3
(1)

While it plays a role in activating CatSper channels, at high concentrations, it might modulate or reduce their expression.