CatSper3 Activators
CatSper3 activators predominantly function by modulating calcium influx or influencing associated pathways that determine sperm capacitation. Progesterone, for instance, is a critical compound that interacts directly with the CatSper complex, causing elevated intracellular calcium concentrations in sperm. On the other hand, chemicals like Forskolin and IBMX exert their influence indirectly by modulating the levels of intracellular cAMP-a key second messenger in sperm cells. Such changes in cAMP concentrations can lead to the activation of various ion channels, including CatSper.
The importance of calcium homeostasis is further underscored by agents like 17β-Estradiol and ATP, which either potentiate calcium influx responses or modulate them through other cellular signaling pathways. A common theme among many of these activators is their ability to influence cellular pathways related to sperm capacitation, which is a priming step necessary for sperm to gain the ability to fertilize an oocyte. Understanding these activators and their mode of action provides deep insights into the sophisticated cellular processes driving sperm function and male fertility.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
17β-Estradiol can potentiate the effect of progesterone on CatSper activation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels, which can indirectly activate CatSper channels. | ||||||
Luteinizing Hormone, β-Subunit | 53664-53-2 | sc-358268 | 50 µg | $1874.00 | ||
LH can indirectly promote CatSper activation through downstream effects on testicular steroidogenesis. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine, via beta-adrenergic receptors, can lead to an increase in intracellular cAMP, potentially influencing CatSper3. | ||||||
Adenosine 5′-Triphosphate, disodium salt | 987-65-5 | sc-202040 sc-202040A | 1 g 5 g | $39.00 $75.00 | 9 | |
ATP serves as a signaling molecule in sperm, indirectly modulating calcium influx through purinergic receptors. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zn²⁺ can modulate sperm function, potentially having an effect on CatSper channels during capacitation. | ||||||
PGE1 (Prostaglandin E1) | 745-65-3 | sc-201223 sc-201223A | 1 mg 10 mg | $31.00 $145.00 | 16 | |
PGE1 can stimulate adenylate cyclase, leading to elevated cAMP levels and potential indirect CatSper activation. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine elevates intracellular cAMP, which might indirectly influence CatSper3 function. | ||||||
Papaverine | 58-74-2 | sc-279951 sc-279951A sc-279951B | 10 mg 50 mg 100 mg | $153.00 $265.00 $459.00 | ||
Papaverine increases cAMP levels, potentially indirectly affecting CatSper3. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a phosphodiesterase inhibitor that can elevate cAMP levels, potentially influencing CatSper3. | ||||||