cathepsin J Inhibitors
Cathepsin J inhibitors constitute a class of compounds designed to modulate the activity of cathepsin J, a protease predicted to enable various functions such as collagen and fibronectin binding activities, as well as participation in processes like collagen catabolic activities and viral entry into host cells. Cathepsin J, located in the Golgi apparatus, multivesicular body, plasma membrane, and active in both the extracellular space and lysosomes, plays a pivotal role in cellular homeostasis and response to extracellular signals. Direct inhibitors like E-64, Leupeptin, CA-074, and Odanacatib specifically target cathepsin J's proteolytic activity, disrupting collagen catabolic processes and fibronectin binding. These inhibitors alter lysosomal and extracellular space functions, potentially impacting processes such as viral entry into host cells. For instance, CA-074 inhibits cathepsin J, influencing its proteolytic activity and potentially affecting viral entry by modulating the protein's role in the plasma membrane.
Indirect inhibitors like FYDM-MA and Wortmannin influence cathepsin J activity by targeting the mTOR and PI3K/Akt signaling pathways, respectively. FYDM-MA modulates collagen catabolic processes and serpin family protein binding, while Wortmannin impacts serpin family protein binding and collagen catabolic processes. These indirect inhibitors provide insights into potential regulatory mechanisms of cathepsin J within cellular signaling pathways, revealing how altering these pathways can influence the protein's functions in diverse cellular compartments. The complex interplay of these inhibitors unveils the intricate network of cathepsin J's involvement in cellular processes. The modulation of cathepsin J activity through direct and indirect inhibitors offers a nuanced approach to unraveling its role in extracellular matrix interactions, viral entry, and other critical cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $281.00 $947.00 $1574.00 | 14 | |
Direct inhibitor of cathepsin J, targeting its proteolytic activity. Disrupts collagen catabolic processes and fibronectin binding activity. Influences lysosomal and extracellular space functions, potentially impacting processes like viral entry into host cells. | ||||||
Leupeptin hemisulfate | 103476-89-7 | sc-295358 sc-295358A sc-295358D sc-295358E sc-295358B sc-295358C | 5 mg 25 mg 50 mg 100 mg 500 mg 10 mg | $73.00 $148.00 $316.00 $499.00 $1427.00 $101.00 | 19 | |
Direct inhibitor of cathepsin J, inhibiting its proteolytic activity. Modulates collagen catabolic processes and serpin family protein binding activity. Alters lysosomal and extracellular space functions, potentially influencing viral entry into host cells. | ||||||
CA-074 | 134448-10-5 | sc-202513 | 1 mg | $321.00 | ||
Direct inhibitor targeting cathepsin J, specifically inhibiting its proteolytic activity. Disrupts fibronectin binding and collagen catabolic processes. Alters lysosomal and extracellular space functions, potentially impacting processes like viral entry into host cells. | ||||||
Odanacatib | 603139-19-1 | sc-364675 sc-364675A sc-364675B | 5 mg 25 mg 250 mg | $218.00 $993.00 $1982.00 | 2 | |
Direct inhibitor of cathepsin J, modulating its proteolytic activity. Influences collagen catabolic processes and serpin family protein binding activity. Alters lysosomal and extracellular space functions, potentially impacting processes like viral entry into host cells. | ||||||
Z-FA-FMK | 197855-65-5 | sc-201303 sc-201303A | 1 mg 5 mg | $128.00 $372.00 | 19 | |
Direct inhibitor targeting cathepsin J, specifically inhibiting its proteolytic activity. Disrupts serpin family protein binding and fibronectin binding activities. Alters lysosomal and extracellular space functions, potentially influencing processes like viral entry into host cells. | ||||||
Calpeptin | 117591-20-5 | sc-202516 sc-202516A | 10 mg 50 mg | $121.00 $456.00 | 28 | |
Indirect inhibitor of cathepsin J, influencing its activity through interference with the mTOR signaling pathway. Modulates collagen catabolic processes and serpin family protein binding. Alters lysosomal and extracellular space functions, potentially impacting processes like viral entry into host cells. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Indirect inhibitor of cathepsin J, influencing its activity through the PI3K/Akt signaling pathway. Alters serpin family protein binding and collagen catabolic processes. Modulates lysosomal and extracellular space functions, potentially impacting processes like viral entry into host cells. | ||||||