CAP1 Inhibitors
The chemical class of CAP1 Inhibitors encompasses a range of compounds that indirectly influence the function of CAP1 by targeting various aspects of actin filament dynamics and related signaling pathways. These inhibitors do not directly target CAP1 but affect its function by altering the actin cytoskeleton, which is central to CAP1's role.
In this class, compounds like Latrunculin A, Cytochalasin D, Jasplakinolide, Swinholide A, and Phalloidin directly target actin filaments by either destabilizing or stabilizing them. This directly contrasts with CAP1's role in regulating actin filament turnover, thereby indirectly inhibiting its function. Further, inhibitors that target actin-myosin interactions or actin polymerization dynamics, such as ML-7, Y-27632, Blebbistatin, CK-666, SMIFH2, Wiskostatin, and Tropomyosin, represent a broader approach. By modulating the dynamics of actin filaments and related proteins, these compounds can indirectly impact CAP1's function in cytoskeletal rearrangements.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Disrupts actin polymerization by binding to G-actin, potentially inhibiting CAP1’s role in actin filament dynamics. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Inhibits actin polymerization by capping F-actin filaments, indirectly affecting CAP1 function. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Stabilizes F-actin and prevents its depolymerization, potentially countering CAP1’s actin-severing activity. | ||||||
Swinholide A, Theonella swinhoei | 95927-67-6 | sc-205914 | 10 µg | $135.00 | ||
Severs actin filaments, potentially competing with CAP1’s role in actin filament dynamics. | ||||||
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $234.00 | 33 | |
Stabilizes F-actin and could indirectly inhibit CAP1 by preventing actin filament turnover. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
An inhibitor of myosin light chain kinase, could indirectly affect CAP1 by altering actin-myosin interactions. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
A ROCK inhibitor, potentially influencing cytoskeletal dynamics and indirectly CAP1’s function. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Inhibits myosin II, potentially impacting actin filament dynamics and indirectly affecting CAP1. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
An Arp2/3 complex inhibitor, could indirectly influence CAP1 by altering actin filament branching. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
Inhibits formin-mediated actin assembly, potentially affecting CAP1 function by altering the dynamics of actin polymerization. | ||||||