CALML4 Activators
CALML4 activators are a class of chemical compounds that specifically target and modulate the activity of the protein calmodulin-like 4 (CALML4). CALML4 is a member of the EF-hand domain-containing protein family, which is characterized by a helix-loop-helix structural motif that can bind calcium ions. This family of proteins plays a crucial role in calcium signaling by interpreting and responding to changes in intracellular calcium levels, which are pivotal for various cellular functions. CALML4, like its relatives, acts as a calcium sensor and can undergo conformational changes upon binding to calcium, which in turn can influence its interaction with other proteins and cellular components.
Activators of CALML4 are specialized molecules that increase the activity of CALML4, often by promoting its ability to bind calcium or by stabilizing the protein in an active conformation. The mechanism by which these activators function can vary, with some directly interacting with the protein's calcium-binding sites, while others may bind to different regions of the protein to exert their effects. The activation of CALML4 by these compounds results in the modulation of CALML4's normal function within the cell. Since CALML4 is involved in intricate cellular processes, the precise regulation of its activity through such activators is a subject of interest in biochemistry and molecular biology. Understanding how CALML4 activators work at a molecular level contributes to a deeper grasp of calcium signaling pathways and the complex network of interactions governing cellular physiology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Calcium | 7440-70-2 | sc-252536 | 5 g | $209.00 | ||
Calcium ions directly interact with CALML4, as it is a calcium-binding protein. The binding of calcium ions to CALML4 leads to conformational changes that activate the protein’s function in cellular signaling pathways. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $166.00 $306.00 $1675.00 | 18 | |
W-7 binds to calmodulin and CALML4, altering their conformation and enhancing their interaction with target enzymes and signaling molecules, thereby potentially increasing CALML4's activation state. | ||||||
Phosphatidyl-L-serine | 51446-62-9 | sc-507548 | 10 g | $46.00 | ||
Phosphatidylserine can interact with calcium-binding proteins like CALML4, facilitating the membrane association and enhancing its role in signal transduction processes. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
KN-93 inhibits CaMKII, which can regulate the function of downstream calcium-binding proteins like CALML4, leading to an indirect enhancement of CALML4 activity by preventing its phosphorylation and inactivation. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $84.00 $196.00 $817.00 | ||
Bay K 8644 activates voltage-gated calcium channels, leading to an influx of calcium ions that could bind to and activate CALML4. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases cAMP levels, which can lead to the activation of PKA. PKA can phosphorylate proteins that interact with CALML4, potentially altering its activity. | ||||||
8-Bromo-cADP-Ribose (8-Br-cADPR) | 151898-26-9 | sc-201514 sc-201514B | 100 µg 1 mg | $133.00 $561.00 | 12 | |
8-Br-cADPR stimulates the release of calcium from the endoplasmic reticulum, thereby indirectly increasing the calcium available for binding to CALML4 and enhancing its activity. | ||||||