Molecular structure of 8-Bromo-cADP-Ribose (8-Br-cADPR), CAS Number: 151898-26-9
8-Bromo-cADP-Ribose (8-Br-cADPR) (CAS 151898-26-9)
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Alternate Names:
8-Bromo-cADP-Ribose (8-Br-cADPR) is also known as 8-bromo-cADPR.
Application:
8-Bromo-cADP-Ribose (8-Br-cADPR) is a cell permeable antagonist of cADPR, shown to block cADPR from inducing Ca2+ release.
CAS Number:
151898-26-9
Purity:
95%
Molecular Weight:
620.19
Molecular Formula:
C15H20BrN5O13P2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
8-Bromo-cADP-Ribose (8-Br-cADPR) is a cell permeable antagonist of cADPR (sc-201512) that may act to block cADPR from inducing Ca2+ release from sea-urchin-egg homogenates. It has also been observed to regulate calcium release from the sarcoplasmic and endoplasmic reticulum. 8-Bromo-cADP-Ribose (8-Br-cADPR) displays the capacity to inhibit arrhythmogenic oscillations of intracellular Ca2+ in heart cells. Additionally, it has been reported to be an endogenous metabolite of beta-NAD+.
8-Bromo-cADP-Ribose (8-Br-cADPR) (CAS 151898-26-9) References
- An antagonist of cADP-ribose inhibits arrhythmogenic oscillations of intracellular Ca2+ in heart cells. | Rakovic, S., et al. 1999. J Biol Chem. 274: 17820-7. PMID: 10364226
- Nitric oxide inhibits Ca(2+) mobilization through cADP-ribose signaling in coronary arterial smooth muscle cells. | Yu, JZ., et al. 2000. Am J Physiol Heart Circ Physiol. 279: H873-81. PMID: 10993745
- Ca(2+) release from ryanodine-sensitive store contributes to mechanism of hypoxic vasoconstriction in rat lungs. | Morio, Y. and McMurtry, IF. 2002. J Appl Physiol (1985). 92: 527-34. PMID: 11796660
- Functional relation between caffeine- and muscarine-sensitive Ca2+ stores and no Ca2+ releasing action of cyclic adenosine diphosphate-ribose in guinea-pig adrenal chromaffin cells. | Ohta, T., et al. 2002. Neurosci Lett. 326: 167-70. PMID: 12095648
- Modulation of spontaneous transient Ca2+-activated K+ channel currents by cADP-ribose in vascular smooth muscle cells. | Cheung, DW. 2003. Eur J Pharmacol. 458: 57-9. PMID: 12498907
- A minimal structural analogue of cyclic ADP-ribose: synthesis and calcium release activity in mammalian cells. | Guse, AH., et al. 2005. J Biol Chem. 280: 15952-9. PMID: 15713671
- Intracellular calcium involvement in pituitary adenylate cyclase-activating polypeptide stimulation of growth hormone and gonadotrophin secretion in goldfish pituitary cells. | Sawisky, GR. and Chang, JP. 2005. J Neuroendocrinol. 17: 353-71. PMID: 15929741
- Role of cyclic ADP-ribose in Ca2+-induced Ca2+ release and vasoconstriction in small renal arteries. | Teggatz, EG., et al. 2005. Microvasc Res. 70: 65-75. PMID: 16095628
- Effects on kidney filtration rate by agmatine requires activation of ryanodine channels for nitric oxide generation. | Satriano, J., et al. 2008. Am J Physiol Renal Physiol. 294: F795-800. PMID: 18199604
- Release-enhancing pre-synaptic muscarinic and nicotinic receptors co-exist and interact on dopaminergic nerve endings of rat nucleus accumbens. | Grilli, M., et al. 2008. J Neurochem. 105: 2205-13. PMID: 18298664
- Oxytocin-induced elevation of ADP-ribosyl cyclase activity, cyclic ADP-ribose or Ca(2+) concentrations is involved in autoregulation of oxytocin secretion in the hypothalamus and posterior pituitary in male mice. | Lopatina, O., et al. 2010. Neuropharmacology. 58: 50-5. PMID: 19540855
- Modulation of the excitability of stellate neurons in the ventral cochlear nucleus of mice by TRPM2 channels. | Bal, R., et al. 2020. Eur J Pharmacol. 882: 173163. PMID: 32485244
- Proteomic profiling of the rat hippocampus from the kindling and pilocarpine models of epilepsy: potential targets in calcium regulatory network. | Sadeghi, L., et al. 2021. Sci Rep. 11: 8252. PMID: 33859251
- Synthesis and characterization of antagonists of cyclic-ADP-ribose-induced Ca2+ release. | Walseth, TF. and Lee, HC. 1993. Biochim Biophys Acta. 1178: 235-42. PMID: 8395888
- Actions of cADP-ribose and its antagonists on contraction in guinea pig isolated ventricular myocytes. Influence of temperature. | Iino, S., et al. 1997. Circ Res. 81: 879-84. PMID: 9351463
Inhibitor of:
CD39.Activator of:
CALML4, and IP3R-III.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
8-Bromo-cADP-Ribose (8-Br-cADPR), 100 µg | sc-201514 | 100 µg | $133.00 | |||
8-Bromo-cADP-Ribose (8-Br-cADPR), 1 mg | sc-201514B | 1 mg | $561.00 |