CAGE Activators
CAGE activators constitute a diverse class of chemicals with the unified characteristic of modulating the function of the CAGE protein, specifically bolstering its role in cellular processes. Given that CAGE is posited to have a profound role in cellular adhesion, the chemicals under this umbrella can directly or indirectly intensify adhesion mechanisms. Phorbol 12-myristate 13-acetate (PMA) is a pertinent example, acting as a PKC activator. By augmenting adhesion-related signaling pathways possibly associated with PKC, PMA can lead to the upregulation of CAGE's function. Similarly, Lysophosphatidic acid (LPA) and Sphingosine-1-Phosphate (S1P) are lipid signaling molecules known to stimulate cellular adhesion. When CAGE operates within the bounds of LPA or S1P-mediated pathways, these activators serve to promote its function, fortifying adhesion processes.
Diving deeper into the chemical composition of CAGE activators, many of these compounds hail from diverse chemical backgrounds, ranging from endocannabinoids like Anandamide to polyphenols such as Epigallocatechin gallate (EGCG). While their chemical structures and primary roles in cellular metabolism vary, their convergent feature remains their ability to influence cellular adhesion. Compounds such as Mangiferin, Oleanolic acid, and Retinoic Acid, though chemically distinct, all have shown capabilities to enhance cellular adhesion in specific contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PKC activator that directly augments adhesion-related signaling, potentially enhancing CAGE's function if associated with PKC-regulated pathways. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $96.00 $334.00 | 50 | |
LPA is known to activate cellular adhesion through its receptors. It can promote CAGE function if CAGE is part of the LPA-induced adhesion pathway. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P signaling can directly stimulate cellular adhesion, potentially enhancing CAGE's role if it's associated with S1P-mediated pathways. | ||||||
Mangiferin | 4773-96-0 | sc-491041 | 10 mg | $140.00 | ||
Known to enhance cellular adhesion properties in certain cell types. If CAGE plays a role in similar processes, Mangiferin may boost its activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Known to promote cell adhesion in some contexts. EGCG could bolster CAGE's activity if CAGE is linked with the pathways affected by EGCG. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
In certain concentrations, it can promote cell adhesion. If CAGE is influenced by oxidative stress-related adhesion, H2O2 might enhance its function. | ||||||
Oleanolic Acid | 508-02-1 | sc-205775 sc-205775A | 100 mg 500 mg | $84.00 $296.00 | 8 | |
It's been shown to enhance cellular adhesion in some cell types. If CAGE is part of pathways influenced by oleanolic acid, its function may be promoted. | ||||||
Uridine 5′-diphosphate sodium salt | 21931-53-3 | sc-222401 sc-222401A | 25 mg 100 mg | $37.00 $77.00 | ||
A pyrimidine nucleoside that can affect cellular adhesion. If CAGE is involved in adhesion processes influenced by UDP, its activity might be bolstered. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $36.00 $102.00 $569.00 $1173.00 | 10 | |
Fatty acid that might enhance certain adhesion processes. If CAGE is tied to pathways modulated by oleic acid, its function can be enhanced. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
A metabolite of Vitamin A known to influence cell adhesion. If CAGE functions within the retinoic acid-modulated pathways, its activity can be enhanced. | ||||||