cadherin-24 Inhibitors
Cadherin-24 inhibitors play a vital role in the modulation of cell adhesion, a process fundamental to tissue morphogenesis and maintenance of tissue integrity. These inhibitors target various pathways and cellular components that indirectly influence cadherin-24 functionality. For instance, some inhibitors work by destabilizing the actomyosin complex, which is essential for cadherin-24 to maintain cellular junctions. Others stabilize proteins that, when accumulated, can competitively interfere with cadherin-24 binding to its partners, ultimately compromising its adhesive capabilities. Additionally, some inhibitors can disrupt the processing and trafficking of cadherin-24 to the cell membrane, where it is actively involved in cell-cell adhesion, thus diminishing its functional presence on the cell surface.
Inhibition of signaling pathways that converge on cadherin-24 is another strategy employed by certain inhibitors. By blocking specific kinases within the MAPK pathway, these inhibitors can attenuate cadherin-24-mediated signaling crucial for cell adhesion processes. Moreover, the manipulation of intracellular calcium levels or cAMP can lead to conformational changes in cadherin-24, affecting its adhesion properties. Other inhibitors target the integrity of the actin cytoskeleton, which is fundamental for the function of cadherin-24, by impeding factors involved in cytoskeletal dynamics and cell motility. Additionally, the modulation of the Wnt/β-catenin signaling pathway, which is intimately linked to cadherin-24, reflects the complexity of the inhibitory mechanisms that ultimately result in reduced cadherin-24 activity and altered cell-cell adhesion dynamics.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $71.00 $260.00 $485.00 $949.00 | ||
An inhibitor of non-muscle myosin II ATPase activity, blebbistatin disrupts actomyosin contractility, which is crucial for cell adhesion processes. Cadherin-24 is reliant on the actin cytoskeleton for its adhesive functions, so by impairing actomyosin interactions, blebbistatin indirectly inhibits cadherin-24-mediated cell adhesion. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $35.00 $115.00 $515.00 | 26 | |
A tankyrase inhibitor that stabilizes axin by preventing its poly-ADP-ribosylation, leading to β-catenin degradation. Cadherin-24 is part of the catenin complex, and its function is closely associated with β-catenin's cellular levels. XAV939's action indirectly leads to a reduction of cadherin-24's functionality in cell-cell adhesion. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
MEK inhibitor that specifically blocks the activation of ERK1/2 in the MAPK pathway. Cadherin-24-mediated signaling can be modulated by the MAPK pathway, and the inhibition of MAPK signaling can therefore lead to reduced cadherin-24 activity in cells. | ||||||
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $94.00 $286.00 | 27 | |
Inhibitor of Wnt production, decreasing β-catenin signaling. Since cadherin-24 interacts with β-catenin, reducing Wnt signaling indirectly decreases cadherin-24's adhesive signaling capabilities by affecting β-catenin availability. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $148.00 $597.00 | 75 | |
A Rac1 inhibitor that disrupts Rac1 interaction with its GEFs, leading to actin cytoskeletal rearrangements. Cadherin-24's adhesive function is dependent on the integrity of the actin cytoskeleton, and inhibiting Rac1 can thereby attenuate cadherin-24's role in cell-cell adhesion. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
Proteasome inhibitor that prevents the degradation of cytosolic proteins, including those that interact with the cadherin-catenin complex. Accumulation of such proteins can competitively inhibit cadherin-24's binding to its partners, indirectly reducing its adhesive function. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
A ROCK inhibitor that impedes stress fiber formation and thus affects cell shape and motility. Through its effects on the actin cytoskeleton, Y-27632 indirectly impairs cadherin-24-mediated cell-cell adhesion. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $99.00 $335.00 $836.00 $2099.00 | 47 | |
A γ-secretase inhibitor that prevents the cleavage of many transmembrane proteins, including members of the cadherin family. By inhibiting γ-secretase, DAPT could indirectly inhibit cadherin-24 by impeding its processing and trafficking to the cell membrane where it exerts its function. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
SERCA pump inhibitor that raises intracellular calcium levels. Elevated calcium can indirectly inhibit cadherin-24 by promoting its endocytosis or by altering its conformation and adhesive properties. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
An adenylate cyclase activator that raises intracellular cAMP levels, which can modulate cell adhesion molecules. Increased cAMP can result in altered cadherin-24 mediated adhesion through changes in the phosphorylation and localization of adhesion components. | ||||||