cadherin-18 Activators
Cdh18, identified as a cadherin, plays a pivotal role in cellular adhesion, orchestrating key events in development and tissue organization. Predicted to exhibit cadherin binding activity and calcium ion binding activity, Cdh18 is intricately involved in calcium-dependent cell-cell adhesion, cell morphogenesis, and the organization of cell-cell junctions. Operating within adherens junctions, Cdh18 contributes to the establishment and maintenance of intercellular connections, facilitating coordinated cell behavior in various tissues. The protein's presence in structures such as the central nervous system, eye, and testis underscores its significance in diverse physiological contexts.
The activation of Cdh18 is a sophisticated process involving intricate molecular mechanisms and signaling pathways. While direct activators might be elusive, several indirect activators have been identified that impact the expression and function of Cdh18. These activators modulate diverse pathways, including Wnt signaling, PKC activation, and histone deacetylation, influencing the transcriptional and post-translational regulation of Cdh18. The interplay of these pathways converges on the regulation of calcium-dependent cell-cell adhesion and the organization of cell-cell junctions. Redox signaling, protein phosphatase activity, and PI3K/Akt pathways also contribute to Cdh18 activation, highlighting the intricate regulatory network that governs the protein's function. Understanding these nuanced molecular interactions provides valuable insights into the fundamental processes of cell adhesion and morphogenesis, shedding light on the broader landscape of cellular communication and tissue development.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a vitamin A derivative, indirectly activates Cdh18 by modulating cellular differentiation pathways. It influences the expression of Cdh18, promoting calcium-dependent cell-cell adhesion and contributing to cell morphogenesis and junction organization. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride, a GSK-3β inhibitor, indirectly stimulates Cdh18 by modulating Wnt signaling. Its impact on the canonical Wnt pathway influences Cdh18 expression, promoting adherens junction activity and enhancing calcium-dependent cell-cell adhesion. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA, a PKC activator, indirectly enhances Cdh18 by activating PKC. This triggers downstream signaling cascades, influencing the organization of cell-cell junctions and contributing to calcium-dependent adhesion. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate, a histone deacetylase inhibitor, indirectly upregulates Cdh18 by influencing epigenetic modifications. It enhances the accessibility of Cdh18 to its target genes, promoting calcium-dependent cell-cell adhesion and contributing to cell morphogenesis. | ||||||
Tiron | 149-45-1 | sc-253699 sc-253699A | 10 g 25 g | $29.00 $41.00 | 11 | |
Tiron, a superoxide dismutase mimetic, indirectly stimulates Cdh18 by modulating redox signaling. Its impact on cellular oxidative stress influences Cdh18 expression, contributing to the organization of cell-cell junctions and calcium-dependent cell-cell adhesion. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A, a protein phosphatase inhibitor, indirectly activates Cdh18 by influencing cellular phosphatase activity. Its impact on phosphorylation pathways enhances Cdh18 expression, contributing to calcium-dependent cell-cell adhesion and the organization of cell-cell junctions. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
BAPTA-AM, a calcium chelator, indirectly activates Cdh18 by modulating intracellular calcium levels. Its impact on calcium signaling pathways influences Cdh18 expression, promoting calcium-dependent cell-cell adhesion and contributing to the organization of cell-cell junctions. | ||||||