cadherin-18 Inhibitors
Cadherin-18, also known as K-cadherin, is a calcium-dependent cell adhesion protein involved in the regulation of cell-cell adhesion and tissue organization. This transmembrane glycoprotein is part of the cadherin superfamily, playing a crucial role in the maintenance of tissue integrity by mediating homophilic interactions between adjacent cells. Cadherin-18 is predominantly expressed in the adult lung and has been implicated in pulmonary tissue development and homeostasis. The primary function of cadherin-18 lies in its ability to mediate calcium-dependent cell adhesion, facilitating the formation of stable intercellular junctions. This adhesive property is crucial for tissue morphogenesis, cell migration, and the maintenance of tissue architecture. Cadherin-18 achieves this by forming transmembrane complexes that link the cytoplasmic domains to the actin cytoskeleton, contributing to cellular cohesion.
Inhibition of cadherin-18 function can be achieved through various chemical compounds targeting different signaling pathways associated with cell adhesion and migration. The presented inhibitors target key cellular processes and signaling cascades, indirectly influencing cadherin-18 activity. For instance, TAE226 disrupts focal adhesion kinase (FAK) activity, leading to altered integrin-mediated signaling and subsequent effects on cadherin-18-mediated adhesion. Similarly, NSC 23766 inhibits Rac1, impacting cytoskeletal organization and cell migration, thereby influencing cadherin-18 function indirectly. Other inhibitors, such as Y-27632 and JNK Inhibitor II, target Rho-associated protein kinase (ROCK) and c-Jun N-terminal kinase (JNK), respectively, affecting downstream MAPK signaling pathways. These compounds modulate cellular processes involved in adhesion, migration, and cytoskeletal dynamics, indirectly influencing cadherin-18 function. In summary, the chemical class of cadherin-18 inhibitors comprises compounds that target various signaling pathways associated with cell adhesion and migration. Through the indirect modulation of these pathways, these inhibitors offer a means to study the intricate regulatory mechanisms of cadherin-18 and its role in maintaining tissue integrity and cellular cohesion.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Selective inhibitor of Rho-associated protein kinase (ROCK), influencing actin cytoskeleton dynamics. By modulating ROCK activity, Y-27632 indirectly affects cadherin-18-mediated cell adhesion, as ROCK is involved in the regulation of actin-myosin contractility and cytoskeletal organization. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
PI3K/AKT pathway inhibitor, impacting downstream signaling. By suppressing PI3K activity, LY294002 indirectly influences cadherin-18 function, as the PI3K/AKT pathway is involved in the regulation of cellular processes such as adhesion and migration. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
Inhibitor of the TGF-β type I receptor, affecting TGF-β signaling. By blocking TGF-β signaling, SB-431542 indirectly modulates cadherin-18 function, as TGF-β pathways are implicated in various cellular processes, including cell adhesion and migration. | ||||||
β-Catenin/Tcf Inhibitor, FH535 | 108409-83-2 | sc-221398 sc-221398A | 10 mg 50 mg | $182.00 $374.00 | 7 | |
Wnt/β-catenin signaling pathway inhibitor, affecting downstream events. By inhibiting Wnt signaling, FH535 indirectly influences cadherin-18 function, as the Wnt pathway plays a role in cellular adhesion and migration processes. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
Inhibitor of c-Jun N-terminal kinase (JNK), impacting MAPK signaling. By suppressing JNK activity, JNK Inhibitor II indirectly influences cadherin-18 function, as MAPK pathways are implicated in the regulation of cellular processes such as adhesion and migration. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
Src family kinase inhibitor, affecting tyrosine kinase activity. By inhibiting Src kinases, PP2 indirectly modulates cadherin-18 function, as Src kinases play a role in signaling pathways that regulate cell adhesion and migration. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Phosphoinositide 3-kinase (PI3K) inhibitor, influencing downstream signaling. By blocking PI3K activity, Wortmannin indirectly impacts cadherin-18 function, as the PI3K pathway is involved in the regulation of cellular processes such as adhesion and migration. | ||||||
GDC-0941 | 957054-30-7 | sc-364498 sc-364498A | 5 mg 10 mg | $188.00 $199.00 | 2 | |
Pan-class I PI3K inhibitor, affecting PI3K signaling. By inhibiting PI3K, GDC-0941 indirectly influences cadherin-18 function, as the PI3K pathway is implicated in the regulation of cellular processes such as adhesion and migration. | ||||||