Date published: 2025-9-5

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CA II Inhibitors

CA II inhibitors, also known as carbonic anhydrase II inhibitors, belong to a specific class of chemical compounds that play a crucial role in modulating the activity of the enzyme carbonic anhydrase II (CA II). Carbonic anhydrases are a family of enzymes that catalyze the interconversion of carbon dioxide (CO2) and bicarbonate ions (HCO3-) in various physiological processes. CA II, in particular, is predominantly found in red blood cells, where it assists in the transport of CO2 from tissues to the lungs for exhalation, thus maintaining acid-base balance in the body. CA II inhibitors, as the name suggests, are molecules that inhibit the enzymatic activity of carbonic anhydrase II, and they do so by binding to its active site. Structurally, CA II inhibitors can vary widely, but they typically possess a chemical moiety that can bind to the zinc ion present in the active site of the enzyme. This binding interferes with the enzyme's ability to catalyze the hydration of CO2 to bicarbonate ions, disrupting essential physiological processes. CA II inhibitors have found applications in several fields, including research, where they are used as tools to study the roles of carbonic anhydrases in various biological processes. Furthermore, CA II inhibitors have also been explored for their ability in medical diagnostics, particularly in the context of imaging techniques that rely on the detection of CO2 or pH changes. The development of CA II inhibitors with high selectivity and affinity for the enzyme's active site remains an area of active research, as they hold promise for various applications beyond their intrinsic chemical and biochemical significance.

Items 1 to 10 of 15 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Topiramate

97240-79-4sc-204350
sc-204350A
10 mg
50 mg
$105.00
$362.00
(1)

Topiramate, as a carbonic anhydrase inhibitor, showcases unique interactions with enzyme active sites, leading to altered bicarbonate ion dynamics. Its distinct molecular structure allows for competitive inhibition, impacting pH regulation in various biological systems. The compound's lipophilic characteristics enhance membrane permeability, promoting efficient cellular uptake. Furthermore, its reaction kinetics reveal a multi-faceted engagement with metabolic pathways, influencing overall stability and reactivity in diverse environments.

Verapamil

52-53-9sc-507373
1 g
$367.00
(0)

Blocks L-type calcium channels, reducing Ca^2+ influx.

Dorzolamide Hydrochloride

130693-82-2sc-207596
10 mg
$186.00
(1)

Dorzolamide Hydrochloride functions as a potent inhibitor of carbonic anhydrase, exhibiting specific binding affinity to the enzyme's active site. This interaction disrupts the equilibrium of carbon dioxide and bicarbonate, influencing acid-base balance. Its unique molecular configuration facilitates strong hydrogen bonding and hydrophilic interactions, enhancing solubility in aqueous environments. The compound's kinetic profile indicates rapid onset of action, reflecting its dynamic engagement in biochemical processes.

Benzenesulfonamide

98-10-2sc-239295
sc-239295A
5 g
100 g
$22.00
$23.00
(0)

Benzenesulfonamide acts as a versatile sulfonamide compound, characterized by its ability to form strong hydrogen bonds and engage in dipole-dipole interactions due to its sulfonamide group. This enhances its solubility in polar solvents and facilitates its participation in various nucleophilic substitution reactions. The compound's electronic structure allows for resonance stabilization, influencing its reactivity and making it a key player in diverse chemical pathways. Its unique properties contribute to its role in various synthetic applications.

Methocarbamol

532-03-6sc-211809
sc-211809-CW
1 g
1 g
$205.00
$390.00
(0)

Methocarbamol is a unique compound that exhibits intriguing molecular interactions, particularly through its ability to form transient dipole moments. This characteristic enhances its solubility in various organic solvents, facilitating its participation in complex reaction mechanisms. The compound's steric configuration allows for selective reactivity, influencing its kinetic behavior in nucleophilic attack scenarios. Additionally, its conformational flexibility contributes to its diverse chemical behavior, making it an interesting subject for further study in synthetic chemistry.

Nifedipine

21829-25-4sc-3589
sc-3589A
1 g
5 g
$58.00
$170.00
15
(1)

Selective L-type calcium channel blocker.

Brinzolamide-d5

1217651-02-9sc-217790
sc-217790A
1 mg
2.5 mg
$925.00
$1331.00
(0)

Brinzolamide-d5 is a distinctive compound characterized by its ability to modulate carbonic anhydrase activity through specific binding interactions. Its isotopic labeling enhances tracking in metabolic studies, providing insights into reaction pathways. The compound's unique stereochemistry influences its affinity for enzyme active sites, affecting reaction kinetics. Furthermore, its solubility profile in polar solvents allows for versatile applications in various chemical environments, making it a subject of interest in mechanistic research.

Diltiazem

42399-41-7sc-204726
sc-204726A
1 g
5 g
$209.00
$464.00
4
(1)

Blocks L-type calcium channels, slowing heart rate.

Amlodipine

88150-42-9sc-200195
sc-200195A
100 mg
1 g
$73.00
$163.00
2
(1)

Inhibits L-type calcium channels in vascular smooth muscle.

Nimodipine

66085-59-4sc-201464
sc-201464A
100 mg
1 g
$60.00
$301.00
2
(1)

Selective for cerebral blood vessels to prevent spasms.