C9orf68 Inhibitors

Staurosporine is a well-known kinase inhibitor with a broad spectrum of targets, capable of disrupting multiple signaling cascades that often regulate protein function through phosphorylation. Paclitaxel, a microtubule stabilizer, can indirectly influence proteins that rely on microtubule dynamics for their proper function or localization. Cyclopamine, by inhibiting the Hedgehog pathway, can affect proteins that are involved in or regulated by this developmental signaling route.

Bortezomib and MG132 are proteasome inhibitors; they prevent the degradation of proteins, potentially causing an accumulation of proteins, including misfolded or damaged ones, which can influence numerous cellular processes. LY294002 and PD98059 are inhibitors of the PI3K/Akt and MAPK/ERK pathways, respectively, which are involved in cell survival, proliferation, and differentiation, and could impact proteins regulated by these pathways. SB431542 functions as an inhibitor of the TGF-beta receptor, which may impact proteins involved in the TGF-beta signaling pathway, affecting processes such as cellular proliferation and differentiation. U0126, similar to PD98059, selectively inhibits MEK and can influence the MAPK/ERK signaling pathway. Rapamycin inhibits mTOR, a key regulator in cell growth and metabolism, and could affect proteins that are downstream of the mTOR pathway. NSC23766 inhibits Rac1, which is involved in the regulation of the actin cytoskeleton, potentially influencing proteins associated with cellular structure and signaling. Z-VAD-FMK is a caspase inhibitor that can affect apoptotic pathways, potentially impacting proteins that either regulate or are activated by caspase-dependent processes.