C9orf21 Inhibitors
C9orf21 inhibitors encompass a variety of chemical compounds that exert their inhibitory effect by elevating oxidative stress or impairing the cell's antioxidant defense mechanisms, in which C9orf21 plays a critical role. For instance, some inhibitors interfere with DNA repair processes, leading to an accumulation of oxidative DNA damage that C9orf21 is unable to counteract, thus indirectly diminishing its protective function. Other inhibitors focus on disrupting cellular redox balance by inhibiting key enzymes involved in maintaining this equilibrium, which increases oxidative stress, thereby saturating C9orf21's peroxidase activity and reducing its capacity to neutralize reactive oxygen species. Additionally, certain inhibitors chelate metal ions, potentially decreasing the availability of cofactors that are vital for C9orf21's antioxidant activity, further contributing to the inhibition of its function.
Another facet of C9orf21 inhibition involves compounds that generate oxidative stress either as a primary effect or as a secondary consequence of their primary action. Heavy metals and specific metabolites increase the generation of reactive oxygen species, which can exceed the neutralizing capacity of C9orf21, effectively inhibiting its function. Some inhibitors may also act as radical scavengers themselves, thus reducing the substrateavailability for C9orf21 and indirectly decreasing its activity. Other compounds increase lysosomal pH, causing secondary oxidative stress that challenges C9orf21's ability to maintain cellular redox homeostasis. Moreover, the use of certain compounds leads to glutathione depletion, resulting in an overwhelming increase in oxidative load that C9orf21 cannot efficiently manage, leading to its functional inhibition.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
PARP inhibitor that prevents the repair of single-strand DNA breaks. Given that C9orf21 is involved in oxidative stress response, the inhibition of DNA repair mechanisms can lead to an accumulation of oxidative DNA damage, indirectly inhibiting the function of C9orf21 in protecting against such damage. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $58.00 $95.00 $245.00 $727.00 | 8 | |
A polyphenol with antioxidant properties that can chelate metal ions, potentially reducing the availability of cofactors required by C9orf21 for its antioxidant activity, which indirectly inhibits C9orf21's ability to mitigate oxidative stress. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Dihydrofolate reductase inhibitor that disrupts folate metabolism, leading to increased oxidative stress. This could overwhelm the peroxidase activity of C9orf21, effectively reducing its functional capacity to counteract reactive oxygen species. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $89.00 $228.00 | ||
Induces oxidative stress by increasing the generation of reactive oxygen species. This elevation in oxidative burden can exceed the neutralizing capacity of C9orf21, thereby indirectly inhibiting its antioxidant function. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Aldehyde dehydrogenase inhibitor that can increase oxidative stress within cells. This heightened oxidative environment can saturate the peroxidase activity of C9orf21, leading to its functional inhibition. | ||||||
Butylated hydroxyanisole | 25013-16-5 | sc-252527 sc-252527A | 5 g 100 g | $30.00 $98.00 | 1 | |
An antioxidant that can act as a scavenger of free radicals, potentially reducing the substrate availability for C9orf21 and indirectly decreasing its activity in the antioxidant defense mechanism. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
A compound known to increase lysosomal pH and can cause oxidative stress as a secondary effect. This lysosomal stress could indirectly inhibit C9orf21 by increasing the cellular oxidative load beyond the capacity of C9orf21's peroxidase activity. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $153.00 $214.00 $4000.00 | 39 | |
Thioredoxin reductase inhibitor that can destabilize cellular redox balance, leading to oxidative stress. This can indirectly inhibit C9orf21 by imposing an oxidative environment that overwhelms its antioxidant defense capabilities. | ||||||
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $56.00 $183.00 $352.00 | 1 | |
Heavy metal that induces oxidative stress by generating reactive oxygen species. This can indirectly inhibit the activity of C9orf21 by enhancing oxidative damage in cells beyond the neutralizing capacity of C9orf21. | ||||||
Nitrofurantoin | 67-20-9 | sc-212399 | 10 g | $84.00 | ||
Generates reactive oxygen species as a byproduct of its bactericidal activity, leading to oxidative stress. This could indirectly inhibit C9orf21 by increasing the oxidative load in cells, challenging C9orf21's capacity to maintain redox homeostasis. | ||||||