C8orf37 Activators

Cilia and flagella associated protein 418 (CFAP418) is a protein that as its name indicates, is believed to be associated with the structure and function of cilia and flagella. Cilia and flagella are hair-like structures that protrude from the surface of many eukaryotic cells. They play essential roles in cell motility, fluid movement, signaling pathways, and are crucial for the proper functioning of several organ systems.

CFAP418, encoded by the gene of the same name, is thought to be involved in the assembly or maintenance of cilia and flagella. These organelles are composed of microtubules arranged in a characteristic "9+2" structure surrounded by a membrane sheath. The precise role of CFAP418 within this complex architecture is not well-defined, but it may interact with other proteins that contribute to the structural integrity of cilia and flagella or participate in the signaling functions they mediate. Mutations in genes associated with ciliary structure and function can lead to a group of diseases known as ciliopathies. These are often characterized by diverse manifestations ranging from chronic respiratory infections, due to impaired motile cilia in the respiratory tract, to infertility resulting from dysfunctional flagella in sperm cells. While the direct involvement of CFAP418 in ciliopathies has not been conclusively demonstrated, studying this protein could provide insights into the pathophysiology of such diseases.