C4ST-3 Activators
Carbohydrate (chondroitin 4) sulfotransferase 3 (C4ST-3) is an enzyme that plays a critical role in the modification of chondroitin sulfate, a key component of the extracellular matrix. The activity of C4ST-3 is pivotal in the sulfation process, which confers specific biological functions on chondroitin sulfate, including its interaction with various proteins and its contribution to the structural integrity of the cellular environment. The expression of C4ST-3 is regulated by a complex network of cellular signals, and its induction is tightly controlled to maintain cellular and tissue homeostasis. Understanding which molecules can induce the expression of C4ST-3 is of significant interest in the field of biochemistry and molecular biology, as these molecules can be crucial for modulating the extracellular matrix's composition and function in various biological contexts.
Several chemical compounds have been identified that can potentially act as activators to induce the expression of C4ST-3. Retinoic acid, for example, is known to play a role in cell differentiation and development and may have a role in promoting C4ST-3 expression to facilitate extracellular matrix maturation. Similarly, Dexamethasone, a glucocorticoid, could influence the expression of C4ST-3 as part of the cellular response to inflammation. Compounds like Forskolin and Phorbol 12-myristate 13-acetate (PMA) exert their effects by activating intracellular signaling cascades that can lead to increased expression of a variety of genes, including those involved in the biosynthesis of sulfated glycosaminoglycans. Moreover, epigenetic modifiers such as Sodium Butyrate and Trichostatin A (TSA), which affect chromatin structure and gene accessibility, could also play a significant role in upregulating C4ST-3 expression by altering the transcriptional landscape. These activators, among others, highlight the diverse array of molecules that can influence the expression of C4ST-3, reflecting the intricate regulation of this enzyme in the context of cellular function and extracellular matrix dynamics.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can upregulate gene expression related to cell differentiation and development, potentially leading to increased C4ST-3 expression in cells synthesizing extracellular matrix components. | ||||||
DHEA | 53-43-0 | sc-202573 | 10 g | $109.00 | 3 | |
As a precursor to sex steroids, DHEA may stimulate the biosynthesis of glycosaminoglycans, thus promoting a rise in C4ST-3 levels to support sulfation processes. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Cholecalciferol, through its hormonal activity, could stimulate cellular pathways that lead to the synthesis of extracellular matrix molecules, including enzymes like C4ST-3 that sulfate chondroitin. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride activates the Wnt signaling pathway, which can lead to the transcriptional activation of genes related to extracellular matrix synthesis, possibly including C4ST-3. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone, a synthetic glucocorticoid, could upregulate the expression of genes involved in the inflammatory response, which may include those encoding enzymes for matrix remodeling such as C4ST-3. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
Hydrogen peroxide, by inducing oxidative stress, could stimulate a cellular response that includes the upregulation of genes responsible for extracellular matrix repair and maintenance, potentially increasing C4ST-3 expression. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
β-Estradiol may upregulate the expression of genes involved in tissue development and repair, which could include those encoding sulfotransferases like C4ST-3. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to an increase in cAMP, which can stimulate the expression of genes involved in cellular growth and matrix production, including potentially C4ST-3. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C, which may lead to increased transcriptional activity of genes involved in cell proliferation and differentiation, including those related to sulfotransferases. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate, as a histone deacetylase inhibitor, can lead to chromatin remodeling, which may enhance the transcription of certain genes, including those encoding enzymes like C4ST-3. | ||||||