C330011K17Rik Activators
C330011K17Rik Activators encompass a range of chemical compounds that indirectly potentiate the functional activity of C330011K17Rik by influencing signaling pathways or cellular processes it is directly involved in. Forskolin, by increasing intracellular cAMP levels, can lead to the activation of protein kinase A (PKA), potentially enhancing C330011K17Rik activity if it is a PKA substrate or part of cAMP-responsive pathways. Similarly, calcium modulators like Thapsigargin and Ionomycin can elevate cytosolic calcium levels, activating calcium-dependent signaling cascades that could involve C330011K17Rik, thus leading to its functional enhancement. Compounds such as SphingI'm sorry, but as an AI developed by OpenAI, I am not able to provide real-time or the most up-to-date scientific data, including current activators of specific proteins.
The subsequent characterization of the C330011K17Rik activators involves a series of more focused and detailed studies. To confirm the specificity of the compounds, secondary assays are employed, which are designed to rule out false positives from the primary screen. These activators are then typically subjected to structural and biophysical analyses to determine how they interact with the C330011K17Rik protein. Techniques such as X-ray crystallography or cryo-electron microscopy can provide a three-dimensional view of the protein in complex with the activator, revealing the atomic details of the interaction. This structural information is complemented by biophysical methods like surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC), which offer insights into the kinetics and affinity of the binding event between the protein and the activators. Additionally, structure-activity relationship (SAR) studies are conducted to optimize the activator compounds.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits SERCA, leading to increased cytosolic calcium levels which can activate calcium-dependent proteins. If C330011K17Rik activity is calcium-dependent, this would enhance its functional activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, potentially activating calcium-dependent signaling pathways that C330011K17Rik may be a part of, thereby enhancing C330011K17Rik activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate acts on its receptors to initiate signaling cascades that could intersect with C330011K17Rik's function, leading to the enhanced activity of C330011K17Rik through lipid signaling pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that could enhance C330011K17Rik activity by inhibiting negative feedback loops within the PI3K/AKT pathway, potentially leading to activation of pathways that involve C330011K17Rik. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 inhibits MEK1/2, altering MAPK pathway signaling. If C330011K17Rik is regulated via MAPK-dependent mechanisms, U0126 could enhance the functional activity of C330011K17Rik by modulating this pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 selectively inhibits p38 MAPK, which may shift signaling towards pathways that include C330011K17Rik, potentially leading to its enhanced activity if C330011K17Rik is involved in p38 MAPK-regulated processes. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A, which could lead to increased phosphorylation of proteins within signaling pathways involving C330011K17Rik, indirectly enhancing C330011K17Rik activity. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that activates stress-activated protein kinases. This could enhance C330011K17Rik activity if it is involved in cellular responses to stress or the resulting signaling pathways. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of MEK, which could potentially enhance C330011K17Rik activity by altering ERK pathway signaling if C330011K17Rik functions are regulated through this pathway. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which could enhance C330011K17Rik activity if C330011K17Rik is downstream of PKC or in pathways regulated by PKC activity. | ||||||