C2CD3 Activators
C2CD3 activators represent a group of chemical compounds that indirectly enhance the activity of C2CD3 by influencing various cellular signaling pathways. Forskolin, for instance, increases intracellular cAMP levels and activates PKA, which can phosphorylate proteins that interact with C2CD3, thus potentiating its activity through cAMP-dependent pathways. Inhibitors like LY294002 and Wortmannin target the PI3K pathway, disrupting a primary route of signal transduction and compelling cells to activate compensatory mechanisms that enhance C2CD3 activity. This homeostatic response ensures the continuation of critical cellular functions by upregulating alternative pathways, indirectly leading to increased C2CD3 activity.
Other compounds such as PD98059 and SB203580 selectively inhibit MEK and p38 MAPK, respectively. Interruption of these pathways triggers a cascade of compensatory reactions within the cells, ultimately resulting in the upregulation of C2CD3. The inhibition of PLC by U73122 reduces IP3 and DAG signaling, which similarly initiates a compensatory response leading to heightened C2CD3 activity. Compounds like Genistein exert their effects by inhibiting tyrosine kinases, thereby potentially inducing feedback mechanisms that can elevate C2CD3 activity. Similarly, NF449 and KN-93 hinder G-protein and CaM kinase II signaling, respectively, and such inhibition prompts the cell to activate alternative pathways that enhance C2CD3 activity. C2CD3 activators also include PKC inhibitors such as Go6983 and Chelerythrine, which by suppressing PKC signaling, induce the cell to utilize alternative signaling mechanisms that result in increased C2CD3 activation.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases intracellular cAMP by activating adenylyl cyclase, thereby enhancing PKA activity which can lead to the phosphorylation of proteins involved in the pathways where C2CD3 functions. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that can lead to activation of compensatory pathways increasing the activity of C2CD3 as a homeostatic response to maintain cellular function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 inhibits p38 MAPK, potentially leading to an upregulation of alternative pathways that compensate for this inhibition, resulting in enhanced C2CD3 activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
As a specific MEK inhibitor, PD98059 disrupts the MAPK/ERK pathway, which could lead to the activation of C2CD3 through compensatory cellular mechanisms. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that could enhance C2CD3 activity by triggering a feedback loop that activates related signaling cascades to maintain cellular functions. | ||||||
NF449 | 627034-85-9 | sc-478179 sc-478179A sc-478179B | 10 mg 25 mg 100 mg | $203.00 $469.00 $1509.00 | 1 | |
NF449 is a potent and selective inhibitor of Gs-alpha subunit of G-proteins, which could result in the upregulation of C2CD3 activity through compensatory cellular signaling mechanisms. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
KN-93 is a CaM kinase II inhibitor, which may cause an increase in C2CD3 activity through the induction of compensatory responses in calcium/calmodulin-dependent pathways. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is an inhibitor of PI3K, which can lead to the activation of alternative pathways that upregulate C2CD3 to maintain cellular signaling homeostasis. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $105.00 $299.00 $474.00 | 15 | |
Go6983 is a PKC inhibitor, potentially leading to increased C2CD3 activity as the cell activates compensatory pathways in response to disrupted PKC signaling. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
ML7 is an inhibitor of myosin light chain kinase, and its inhibition may lead to the enhanced activity of C2CD3 as part of a compensatory cellular response. | ||||||