C2CD3 Inhibitors
Chemical inhibitors of C2CD3 target various aspects of the protein's function, which is intrinsically connected to the primary cilium and the Hedgehog (Hh) signaling pathway. Cyclopamine and Jervine operate by directly inhibiting the Hh pathway, thereby disrupting the ciliary structures that are essential for C2CD3's role in ciliogenesis. These chemicals bind to Smoothened, a critical component of the Hh pathway, blocking the signal transduction that would normally take place in the primary cilium. Similarly, inhibitors like Vismodegib, Sonidegib, Saridegib, Taladegib, and Glasdegib also target and inhibit Smoothened, leading to a breakdown in the Hh signaling cascade. This disruption is crucial because C2CD3 is pivotal in the formation and function of the primary cilium and is hence reliant on a functional Hh pathway. The interruption of this pathway by these Smoothened inhibitors directly impacts C2CD3's ciliary functions.
Furthermore, the chemical TWS119 inhibits glycogen synthase kinase-3 beta (GSK-3β), a kinase implicated in microtubule dynamics and ciliogenesis. Since C2CD3 is associated with microtubule-based processes within the primary cilium, GSK-3β inhibition by TWS119 affects C2CD3 by disrupting the microtubule organization necessary for its function. Plerixafor, while not a direct inhibitor of the Hh pathway, impacts ciliary structure and dynamics. Its mode of action, though primarily as a CXCR4 antagonist, has consequences on the cellular conditions required for C2CD3's activity in ciliogenesis.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $94.00 $208.00 | 19 | |
Cyclopamine is a specific inhibitor of the Hedgehog (Hh) signaling pathway. C2CD3 is required for the primary cilium formation, and the Hh signaling pathway is critically dependent on the primary cilium. Inhibition of the Hh pathway by Cyclopamine can therefore functionally inhibit C2CD3 by disrupting the formation and function of the primary cilium where C2CD3 is localized. | ||||||
Jervine | 469-59-0 | sc-200934 sc-200934A | 1 mg 5 mg | $66.00 $240.00 | 1 | |
Jervine functions similarly to Cyclopamine as an inhibitor of the Hedgehog pathway. By impeding the pathway's signaling, Jervine can functionally inhibit C2CD3 activity related to ciliogenesis and Hh signaling. | ||||||
GANT61 | 500579-04-4 | sc-202630 sc-202630A sc-202630B | 1 mg 5 mg 10 mg | $64.00 $131.00 $204.00 | 6 | |
GANT61 is a GLI antagonist that inhibits the transcriptional activity of the GLI family of transcription factors, downstream effectors in the Hedgehog pathway. By doing so, it can indirectly inhibit C2CD3 by impeding the transcriptional activation of target genes involved in cilium assembly and function. | ||||||
Vismodegib | 879085-55-9 | sc-396759 sc-396759A | 10 mg 25 mg | $82.00 $158.00 | 1 | |
Vismodegib is a Hedgehog pathway inhibitor that binds to and inhibits Smoothened, a G-protein-coupled receptor involved in the Hh signaling pathway. By inhibiting Smoothened, Vismodegib can indirectly functionally inhibit C2CD3 by disrupting Hh pathway-dependent ciliary processes. | ||||||
Erismodegib | 956697-53-3 | sc-396280 sc-396280A | 10 mg 100 mg | $255.00 $918.00 | ||
Sonidegib also targets and inhibits Smoothened in the Hh pathway. By blocking Smoothened, Sonidegib can functionally inhibit C2CD3's role in the primary cilium, crucial for Hh signal transduction. | ||||||
Saridegib | 1037210-93-7 | sc-507351 | 5 mg | $3500.00 | ||
Saridegib inhibits the Hh pathway by targeting Smoothened. Inhibition of this pathway can disrupt primary cilia assembly or function, leading to the functional inhibition of C2CD3. | ||||||
Glasdegib | 1095173-27-5 | sc-507353 | 5 mg | $165.00 | ||
Glasdegib is another Smoothened inhibitor, which would functionally inhibit C2CD3 by blocking the Hh signaling necessary for proper ciliogenesis and ciliary function, where C2CD3 is involved. | ||||||