C1orf146 Inhibitors
C1orf146 inhibitors encompass a diverse range of chemical compounds that intricately diminish the functionality of the protein through various cellular pathways and mechanisms. These inhibitors operate on the premise that the inhibition of specific pathways or cellular processes will result in the decreased activity of C1orf146, regardless of whether this protein is directly targeted. For instance, certain inhibitors work by modifying the epigenetic state of the cell, which may affect the expression or function of C1orf146 if it is implicated in chromatinremodeling or gene regulation. The inhibition of histone deacetylases increases acetylation levels, which can lead to a more open chromatin state and potentially reduce the activity of proteins involved in chromatin compaction, such as C1orf146.
On the other hand, compounds that target key signaling pathways, like the mTOR, PI3K/AKT, or MAPK/ERK pathways, can indirectly influence C1orf146 activity. For example, the mTOR pathway is essential for protein synthesis and cell growth, and its inhibition could suppress the activity or expression of C1orf146 if it is regulated by or interacts with components of this pathway. Similarly, by blocking PI3K/AKT signaling, a compound can decrease the activity of downstream proteins that require this signaling for activation or stability, potentially including C1orf146. Furthermore, inhibition of MEK1/2 can halt the ERK1/2 pathway, which is often a requirement for the phosphorylation and activation of numerous cellular proteins. If C1orf146 is among these proteins or is regulated by them, its activity would be diminished. In essence, these inhibitors strategically trigger a cascade of cellular events that lead to reduced C1orf146 functionality by dismantling the framework of signaling pathways and cellular processes that support its activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Histone deacetylase inhibitor that leads to an increase in acetylated histones, thereby affecting the expression of genes. C1orf146, if involved in chromatin remodeling, could have its function impeded as chromatin becomes more relaxed and less accessible for proteins that compact chromatin. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
mTOR inhibitor that blocks the mTOR pathway, which is crucial for protein synthesis and cell growth. If C1orf146 is a protein that is regulated by or interacts with components of this pathway, Rapamycin could diminish its function by suppressing the pathway that supports its activity or expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A potent inhibitor of phosphoinositide 3-kinases (PI3K), which would suppress the PI3K/AKT signaling pathway. If C1orf146 functions downstream of PI3K/AKT signaling, the inhibition of this pathway could lead to a decrease in C1orf146 activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
MEK inhibitor that impedes the MAPK/ERK pathway. This could lead to a decrease in the activity of C1orf146 if it is involved in this signaling cascade or if it is regulated by downstream ERK-mediated phosphorylation events. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
p38 MAP kinase inhibitor that could diminish the activity of C1orf146 by inhibiting stress-activated protein kinase pathways, which might regulate the stability or activity of C1orf146. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Inhibitor of the Rho-associated protein kinase (ROCK). If C1orf146 is involved in cytoskeleton organization and cell motility processes mediated by the Rho/ROCK pathway, inhibition by Y-27632 could lead to diminished C1orf146 activity. | ||||||
2-Methoxyestradiol | 362-07-2 | sc-201371 sc-201371A | 10 mg 50 mg | $70.00 $282.00 | 6 | |
Microtubule destabilizer that could inhibit cell division. If C1orf146 is associated with cell cycle progression, the disruption of microtubules could lead to a reduction in its activity. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
Aurora kinase inhibitor that affects spindle formation and chromosome segregation during mitosis. If C1orf146 plays a role in cell division, inhibition of Aurora kinases could lead to diminished C1orf146 activity related to these processes. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
SERCA pump inhibitor, leading to an increase in cytosolic calcium levels. If C1orf146 function is calcium-dependent or is modulated by calcium signaling pathways, thapsigargin could diminish its activity by disrupting normal calcium homeostasis. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
N-linked glycosylation inhibitor that can cause ER stress and unfolded protein response. If C1orf146 is a glycoprotein or its function relies on glycosylation, tunicamycin could diminish its activity by preventing proper folding and processing. | ||||||