C14orf183 Inhibitors
Inhibitors of C14orf183 operate through a variety of cellular mechanisms to achieve functional suppression of this protein, primarily by intervening in the signaling pathways that modulate its activity. Kinase inhibitors play a significant role in this process, as they disrupt the phosphorylation events essential for the proper functioning of C14orf183. By inhibiting upstream kinases, these compounds prevent the phosphorylation that C14orf183 requires for activation, effectively dampening its activity. In a similar vein, compounds targeting the PI3K/Akt/mTOR pathway, which is integral to cell growth and proliferation, indirectly curtail C14orf183 function by disrupting the signaling necessary for its activity. Since C14orf183 activity is contingent upon the integrity of these pathways, the inhibitors' action results in a consequential decrease in its functional state.
Beyond the kinase pathways, additional inhibitors exert their influence by modulating the cellular stress response mechanisms and transcriptional regulation pathways that indirectly govern C14orf183 activity. Proteasome inhibitors, for example, lead to an accumulation of misfolded proteins and induce cellular stress responses that can suppress the activity of proteins such as C14orf183. Other compounds impact chromatin remodeling and gene expression, thereby altering the availability of transcription factors or co-activators crucial for C14orf183 function.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent, non-selective inhibitor of protein kinases. By inhibiting protein kinases that are crucial for the phosphorylation events required for proper C14orf183 function, Staurosporine indirectly leads to reduced activity of C14orf183 by preventing its essential post-translational modifications. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A specific inhibitor of PI3K which plays a pivotal role in multiple signaling pathways. Inhibition of PI3K leads to a cascade effect, halting the Akt signaling pathway which is necessary for the full activation of C14orf183, ultimately leading to its functional inhibition. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Binds to FKBP12 and blocks the mTOR pathway, which is involved in cell growth and proliferation. By blocking mTOR, Rapamycin indirectly diminishes the activity of downstream proteins that are vital for C14orf183 function, hence leading to its inhibition. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
A specific inhibitor of MEK, which is part of the MAPK/ERK pathway. Blocking MEK leads to a downstream inhibition of ERK, which is implicated in the regulation of C14orf183, thereby inhibiting its activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A selective inhibitor of p38 MAPK. The inhibition of p38 MAPK can result in the decreased activation of transcription factors that regulate C14orf183 activity, thus indirectly inhibiting C14orf183. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of JNK, which plays a role in stress signaling. By inhibiting JNK, SP600125 indirectly impedes the stress response signals that may be necessary for C14orf183 activation or stabilization, leading to reduced activity of C14orf183. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
An irreversible inhibitor of PI3K. Wortmannin's inhibition of PI3K dampens the Akt pathway, which is indirectly necessary for C14orf183 function, thus leading to its inhibition. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
A potent inhibitor of protein kinase C (PKC). The inhibition of PKC results in the disruption of pathways that could potentially involve C14orf183, indirectly leading to a decrease in its functional activity. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
A tyrosine kinase inhibitor that can impede multiple signaling pathways including Src family kinases. As such pathways may be involved in the activation or regulation of C14orf183, Dasatinib indirectly inhibits the functional activity of C14orf183. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
A proteasome inhibitor that can lead to the accumulation of misfolded proteins, inducing stress responses that could downregulate proteins like C14orf183, hence indirectly inhibiting its activity. | ||||||