C14orf148 Inhibitors
NADP Dependent Oxidoreductase Domain Containing 1, often abbreviated as NOR1, is an enzyme that belongs to the family of oxidoreductases. These enzymes are characterized by their ability to catalyze oxidation-reduction reactions, which are fundamental to cellular metabolism. Oxidoreductases play critical roles in various metabolic pathways, including those involved in the metabolism of lipids, amino acids, and carbohydrates, as well as in the detoxification of drugs and xenobiotics.NOR1 specifically is known to contain domains that suggest its activity is dependent on nicotinamide adenine dinucleotide phosphate (NADP+), which is a coenzyme used in anabolic reactions, such as lipid and nucleic acid synthesis, where it functions as an electron donor. The enzyme's activity is also associated with the reduction of reactive oxygen species (ROS), protecting cells from oxidative damage. This protection is vital for maintaining cellular integrity and function, as excessive ROS can lead to oxidative stress, damaging DNA, proteins, and lipids, which in turn is implicated in aging and various diseases including cancer and neurodegenerative disorders.
The precise molecular function of NOR1, as well as the pathways it is involved in and its biological substrates, are still under active investigation. However, it is believed that NOR1's enzymatic activity may involve the conversion of aldehydes and ketones to their corresponding alcohols using NADP+ as a cofactor, reflecting its role in cellular redox homeostasis.Understanding the function of NOR1 is of interest not only for basic science in elucidating the complex network of redox reactions within the cell. Given its potential role in mitigating oxidative stress, NOR1 may be a target for interventions aimed at diseases caused by or associated with oxidative damage.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol may inhibit NADP dependent oxidoreductase domain containing 1 expression by acting as a competitive inhibitor, disrupting the enzyme's activity. It may interfere with the binding of substrates, thus reducing the enzyme's catalytic function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin may inhibit NADP dependent oxidoreductase domain containing 1 expression by modulating various signaling pathways, possibly affecting the expression or activity of the enzyme. It may also interfere with the enzyme's structural integrity, thereby reducing its functionality. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin may inhibit NADP dependent oxidoreductase domain containing 1 expression by potentially acting as a competitive inhibitor, hampering the enzyme's ability to bind to its substrate or cofactor. It may also modulate gene expression, leading to reduced levels of the enzyme. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG may inhibit NADP dependent oxidoreductase domain containing 1 expression by interfering with cellular signaling pathways or gene expression, potentially downregulating the synthesis or stability of the enzyme. It may also directly inhibit the enzyme's catalytic activity. | ||||||
Piperine | 94-62-2 | sc-205809 sc-205809A | 5 g 25 g | $37.00 $146.00 | 3 | |
Piperine may inhibit NADP dependent oxidoreductase domain containing 1 expression by potentially modulating gene expression or affecting the enzyme's post-translational modifications, leading to reduced levels or activity of the enzyme. It may also interfere with the enzyme's binding to substrates. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein may inhibit NADP dependent oxidoreductase domain containing 1 expression by potentially interfering with various signaling pathways, leading to downregulation of the enzyme. It may also affect the enzyme's conformation, stability, or activity, thereby reducing its expression or functionality. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $27.00 $51.00 $101.00 $153.00 $1925.00 | 40 | |
Luteolin may inhibit NADP dependent oxidoreductase domain containing 1 expression by potentially modulating gene expression, leading to reduced levels of the enzyme. It may also act as a competitive inhibitor, interfering with the enzyme's binding to its substrate or cofactor, thus inhibiting its catalytic activity. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $99.00 $216.00 $510.00 | 11 | |
Kaempferol may inhibit NADP dependent oxidoreductase domain containing 1 expression by potentially modulating various signaling pathways, affecting the synthesis, stability, or activity of the enzyme. It may also interfere with the enzyme's binding to substrates or cofactors, thereby inhibiting its function. | ||||||
Silybin | 22888-70-6 | sc-202812 sc-202812A sc-202812B sc-202812C | 1 g 5 g 10 g 50 g | $55.00 $114.00 $206.00 $714.00 | 6 | |
Silibinin may inhibit NADP dependent oxidoreductase domain containing 1 expression by potentially modulating gene expression, leading to reduced levels of the enzyme. It may also interfere with the enzyme's post-translational modifications or stability, thereby affecting its expression or activity. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine may inhibit NADP dependent oxidoreductase domain containing 1 expression by potentially modulating various signaling pathways, leading to downregulation of the enzyme. It may also interfere with the enzyme's structural integrity or binding to substrates, affecting its expression or functionality. | ||||||