C11orf1 Activators
C11orf1 can employ a variety of mechanisms to modulate the activity of this protein, primarily through the alteration of phosphorylation states. Phorbol 12-myristate 13-acetate (PMA), for instance, directly activates protein kinase C (PKC), which is a crucial player in the phosphorylation of cellular proteins. By engaging PKC, PMA can facilitate the phosphorylation and consequent activation of C11orf1, altering its function or interactions within the cell. Similarly, Forskolin, by elevating cyclic AMP (cAMP) levels, activates protein kinase A (PKA), another kinase that can phosphorylate C11orf1, assuming the latter is a substrate for PKA. This activation pathway is echoed by 8-Bromo-cAMP and Dibutyryl-cAMP, both analogs of cAMP that permeate cells and activate PKA, potentially leading to the phosphorylation and activation of C11orf1.
Compounds that influence cellular calcium levels can also impact the activity of C11orf1. Ionomycin increases intracellular calcium concentrations, which can activate calmodulin and calcium-dependent kinases, possibly leading to the phosphorylation of C11orf1. Thapsigargin serves a similar function by inhibiting the SERCA pump, elevating cytosolic calcium levels, and potentially activating calcium-sensitive pathways that phosphorylate C11orf1. Conversely, Calyculin A and Okadaic Acid, both inhibitors of protein phosphatases, prevent the dephosphorylation of proteins, thereby maintaining C11orf1 in a phosphorylated, active state. Anisomycin, through its role as a protein synthesis inhibitor, can activate stress-activated protein kinases such as JNK, which may phosphorylate C11orf1. In contrast, Piceatannol and Staurosporine, through their respective inhibition of tyrosine kinases and protein kinases, can alter the activation state of C11orf1 by modulating the phosphorylation equilibrium. Finally, BIM I, although a PKC inhibitor, can paradoxically activate PKC and thus C11orf1 under certain conditions through allosteric effects. Each of these chemicals, through their unique interactions with cellular signaling pathways, can lead to the modulation of C11orf1 activity, predominantly by influencing its phosphorylation status.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC) which is known to phosphorylate a wide range of cellular proteins. The activation of PKC leads to the phosphorylation and consequent activation of C11orf1 by altering its conformation or its association with other cellular components. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentrations. Calcium is a secondary messenger that can activate calmodulin and calcium-dependent kinases, which may lead to the activation of C11orf1 through phosphorylation or by affecting its interaction with other proteins or substrates. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates PKA. Activation of PKA has the potential to phosphorylate and activate C11orf1 if C11orf1 is within PKA's substrate profile or if C11orf1 is functionally regulated by PKA-mediated signaling. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
Calyculin A is an inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A), which leads to increased phosphorylation of proteins by preventing dephosphorylation. This can result in the sustained activation of C11orf1 if it is normally regulated by dephosphorylation through PP1 or PP2A. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is also an inhibitor of PP1 and PP2A, similar to Calyculin A. By inhibiting these phosphatases, Okadaic Acid can indirectly promote the phosphorylation state and activation of C11orf1, assuming that C11orf1 is regulated by phosphorylation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is another cAMP analog that permeates cells and resists degradation. By mimicking cAMP, it activates PKA, which in turn may phosphorylate and activate C11orf1 if C11orf1 is a part of the PKA signaling network. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that can also activate stress-activated protein kinases like JNK. The activation of JNK can lead to the phosphorylation of C11orf1, assuming that C11orf1 is a downstream effector in the JNK signaling pathway. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that leads to an increase in cytosolic calcium levels. Elevated calcium can activate numerous calcium-sensitive signaling pathways that could result in the activation of C11orf1 through subsequent phosphorylation or allosteric modulation. | ||||||
Piceatannol | 10083-24-6 | sc-200610 sc-200610A sc-200610B | 1 mg 5 mg 25 mg | $50.00 $70.00 $195.00 | 11 | |
Piceatannol inhibits the activity of tyrosine kinases, which can lead to an altered phosphorylation state of downstream proteins. If C11orf1 is regulated by tyrosine kinase activity, the inhibition of these kinases could change the equilibrium of C11orf1 activation through a compensatory mechanism in the cell. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases, known for its nonspecific inhibition, but at low concentrations, it can paradoxically activate certain kinases. If C11orf1 activity is modulated by such kinases, the nuanced alteration in kinase activity by staurosporine could lead to the activation of CIt seems like there may have been a misunderstanding in your request; I provided a table format that might be used for listing compounds and their effects on a hypothetical protein named C11orf1. However, without specific information on the context or the actual research question, the content in the table is speculative and based on general principles of how these compounds affect cellular processes. | ||||||