C030048B08Rik Activators
C030048B08Rik Activators are a collection of chemicals that indirectly promote the functional activity of C030048B08Rik through varied signaling pathways. Forskolin increases the intracellular cAMP levels, which in turn activates PKA, leading to phosphorylation of substrates that could be part of the C030048B08Rik signaling network, thus enhancing its activity. Similarly, PMA and 4-PDD are known to activate PKC, which can phosphorylate targets associated with C030048B08Rik, potentially enhancing its functionality. Ionomycin and Calcimycin, by increasing intracellular calcium levels, activate calcium-dependent kinases that could interact with C030048B08Rik.
C030048B08Rik Activators encompass a range of chemical compounds that indirectly stimulate the functional activity of C030048B08Rik via distinct cellular signaling pathways. Forskolin, by elevating cAMP within the cell, indirectly promotes the functional activity of C030048B08Rik through cAMP-dependent protein kinase A (PKA), which phosphorylates substrates that interact with C030048B08Rik's signaling network. This enhances the protein's activity by modifying the proteins and signaling pathways that C030048B08Rik is directly involved in. The use of phorbol esters like Phorbol 12-myristate 13-acetate (PMA) and 4-Phorbol 12,13-didecanoate (4-PDD) leads to the activation of protein kinase C (PKC), which can also phosphorylate targets linked to C030048B08Rik, potentially augmenting its activity. Ionomycin and Calcimycin act as calcium ionophores, increasing intracellular calcium and activating calcium-dependent kinases, which may indirectly enhance the activity of C030048B08Rik through calcium signaling pathways.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a diacylglycerol analog that activates protein kinase C (PKC). Activated PKC can phosphorylate a wide range of substrates, potentially including those that interact with C030048B08Rik. This phosphorylation can enhance the functional activity of C030048B08Rik through modulation of its associated signaling pathways. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can activate calmodulin-dependent kinases, which in turn may activate signaling pathways involving C030048B08Rik, thereby enhancing its function. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
As a cAMP analog, 8-Bromo-cAMP activates PKA, leading to phosphorylation of targets that may interact with C030048B08Rik, thereby enhancing its activity through these associated pathways. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases PP1 and PP2A, leading to increased phosphorylation levels due to reduced dephosphorylation. This can enhance the activity of C030048B08Rik indirectly by maintaining the phosphorylation state of proteins within its signaling network. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $82.00 $192.00 $801.00 | ||
Bay K8644 is an L-type calcium channel activator, increasing calcium influx. This rise in intracellular calcium can activate pathways in which C030048B08Rik is involved, thus enhancing its activity. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $114.00 $175.00 $260.00 $362.00 $617.00 $1127.00 | ||
Cyclic AMP, as a second messenger, activates PKA. PKA phosphorylates various substrates, potentially including those within the C030048B08Rik signaling network, enhancing the protein's activity. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that also activates stress-activated protein kinases such as JNK. Activation of these pathways can indirectly enhance the activity of C030048B08Rik through stress response or apoptotic signaling pathways. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is a PKC inhibitor that can lead to the compensatory activation of other kinases. These kinases may then enhance the activity of C030048B08Rik through alternative signaling routes that are not primarily regulated by PKC. | ||||||