BTG1 inhibitors represent a class of chemical compounds that have garnered attention in the field of molecular biology and cell cycle regulation. These inhibitors are specifically designed to target and modulate the activity of BTG1, also known as B-cell translocation gene 1. BTG1 is a multifunctional protein that plays a crucial role in various cellular processes, including cell proliferation, differentiation, and apoptosis. It is considered a tumor suppressor gene, as its expression is often downregulated in cancer cells, and it is associated with the regulation of cell cycle progression and the response to external signals.
BTG1 inhibitors exert their effects by interfering with the function or expression of BTG1, disrupting its role in cell cycle regulation and other cellular processes. This interference can lead to alterations in cell proliferation, differentiation, and apoptotic pathways, ultimately impacting cellular behaviors and responses. Researchers utilize BTG1 inhibitors as valuable tools to investigate the specific roles of BTG1 in different cellular contexts and to better understand the molecular mechanisms underlying cell cycle control and cellular differentiation. While the precise applications and broader implications of BTG1 inhibitors continue to be subjects of ongoing research, their utility in elucidating the intricate molecular mechanisms that govern cell fate decisions and cellular responses to external stimuli is of paramount importance in the field of molecular biology and cell biology.
Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
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Diethylstilbestrol | 56-53-1 | sc-204720 sc-204720A sc-204720B sc-204720C sc-204720D | 1 g 5 g 25 g 50 g 100 g | $70.00 $281.00 $536.00 $1076.00 $2142.00 | 3 | |
Diethylstilbestrol is a synthetic estrogen that can modulate estrogen receptor-mediated gene expression, potentially decreasing BTG1 levels. | ||||||
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $55.00 $179.00 $345.00 | 1 | |
Cadmium can disrupt cellular homeostasis and alter gene expression profiles, including downregulation of BTG1 expression. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide inhibits eukaryotic protein synthesis by interfering with the translocation step, decreasing overall protein levels including BTG1. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate is a dihydrofolate reductase inhibitor that affects nucleotide synthesis and can downregulate the expression of some genes. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D intercalates into DNA, inhibiting the transcription process and potentially decreasing BTG1 expression. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide inhibits DNA topoisomerase II, leading to DNA damage and potential downregulation of BTG1 expression. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Cisplatin forms DNA adducts, causing DNA damage and potentially modulating the transcription of various genes including BTG1. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, affecting DNA synthesis and potentially downregulating BTG1 expression. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $87.00 $224.00 | ||
Arsenic trioxide can lead to oxidative stress and modulate signal transduction pathways, potentially decreasing BTG1 expression. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin intercalates into DNA and disrupts topoisomerase-II, which can lead to changes in gene expression, including BTG1. |