BTG1 Antibody (2095C1a): sc-81207

BTG1 Antibody (2095C1a) is a mouse monoclonal IgG1 antibody that detects BTG1 protein of human origin by western blotting (WB) and immunoprecipitation (IP). BTG1 Antibody (2095C1a) is available as a non-conjugated BTG1 monoclonal antibody (2095C1a). BTG1 is a member of the B cell translocation gene family, which plays a crucial role in regulating cell proliferation and transcription. BTG1 functions as an anti-proliferative factor, with expression being induced in response to various mitogenic and differentiative signals. BTG1 is predominantly expressed during the G0/G1 phases of the cell cycle, where BTG1 acts to inhibit progression through G1, thereby preventing uncontrolled cell division. The regulation of BTG1 is vital for maintaining cellular homeostasis and preventing tumorigenesis, as BTG1 downregulation during the G1 phase allows cells to transition into the S phase, where DNA replication occurs. Additionally, BTG1 interacts with other proteins involved in cell cycle regulation, including BTG2, which is known to respond to DNA damage and promote cell cycle arrest. The ability of BTG1 to modulate cell cycle dynamics underscores its importance in cancer biology and therapeutic strategies aimed at targeting cell proliferation.

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BTG1 Antibody (2095C1a) References:

1. Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway.  |  Prévôt, D., et al. 2001. J Biol Chem. 276: 9640-8. PMID: 11136725
2. The gene PC3(TIS21/BTG2), prototype member of the PC3/BTG/TOB family: regulator in control of cell growth, differentiation, and DNA repair?  |  Tirone, F. 2001. J Cell Physiol. 187: 155-65. PMID: 11267995
3. The human BTG2/TIS21/PC3 gene: genomic structure, transcriptional regulation and evaluation as a candidate tumor suppressor gene.  |  Duriez, C., et al. 2002. Gene. 282: 207-14. PMID: 11814693
4. Expression of B-cell translocation gene 2 protein in normal human tissues.  |  Melamed, J., et al. 2002. Tissue Cell. 34: 28-32. PMID: 11989967
5. BTG2 antiproliferative protein interacts with the human CCR4 complex existing in vivo in three cell-cycle-regulated forms.  |  Morel, AP., et al. 2003. J Cell Sci. 116: 2929-36. PMID: 12771185
6. BTG1, a member of a new family of antiproliferative genes.  |  Rouault, JP., et al. 1992. EMBO J. 11: 1663-70. PMID: 1373383
7. Impaired expression of the cell cycle regulator BTG2 is common in clear cell renal cell carcinoma.  |  Struckmann, K., et al. 2004. Cancer Res. 64: 1632-8. PMID: 14996721
8. TIS21/BTG2/PC3 is expressed through PKC-delta pathway and inhibits binding of cyclin B1-Cdc2 and its activity, independent of p53 expression.  |  Ryu, MS., et al. 2004. Exp Cell Res. 299: 159-70. PMID: 15302583
9. Expression of the NF-kappaB-responsive gene BTG2 is aberrantly regulated in breast cancer.  |  Kawakubo, H., et al. 2004. Oncogene. 23: 8310-9. PMID: 15378000
10. Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway.  |  Rouault, JP., et al. 1996. Nat Genet. 14: 482-6. PMID: 8944033

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-BTG1 Antibody (2095C1a) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-BTG1 Antibody (2095C1a) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

BTG1 Antibody (2095C1a) Specifications

Alternate Product Name: BTG1

Product Clone Name: 2095C1a

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: BTG1

Epitope Species: human

Product Reactivity/Detection: BTG1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for BTG1 Antibody (2095C1a): N/A