Brn-3b Inhibitors
Common Brn-3b Inhibitors include, but are not limited to Xanthohumol from hop (Humulus lupulus) CAS 6754-58-1, Curcumin CAS 458-37-7, SF1126 CAS 936487-67-1, Pimozide CAS 2062-78-4 and Xanthohumol from hop (Humulus lupulus) CAS 6754-58-1.
Brn-3b inhibitors belong to a specific chemical class of compounds designed to target and inhibit the activity of Brn-3b, also known as POU4F2 or N-Oct-5. Brn-3b is a transcription factor that belongs to the POU-domain family and plays a critical role in the development and maintenance of sensory neurons, particularly those involved in vision and hearing. It is essential for the specification of neuronal subtypes and the establishment of neural circuitry.
Brn-3b inhibitors work by specifically targeting the Brn-3b transcription factor, interfering with its ability to bind to DNA and regulate the expression of target genes. By doing so, these inhibitors may modulate the transcriptional programs that guide the differentiation and functional properties of sensory neurons. Research into Brn-3b inhibitors is ongoing to unravel their precise mechanisms of action and explore their implications in understanding neural development and sensory processing. The study of Brn-3b inhibitors contributes to a deeper understanding of the intricate mechanisms governing neuronal diversity and sensory function.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Xanthohumol from hop (Humulus lupulus) | 6754-58-1 | sc-301982 | 5 mg | $354.00 | 1 | |
Xanthohumol is a natural compound found in hops. It has been suggested to inhibit Brn-3b by interfering with its transcriptional activity. Xanthohumol may modulate downstream target genes regulated by Brn-3b, affecting its role in cell differentiation and tumorigenesis. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is a natural compound with anti-inflammatory and anti-cancer properties. It has been proposed to modulate Brn-3b expression and activity, potentially affecting its role in promoting cell survival and proliferation in certain cancer contexts. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a natural polyphenol, has been proposed to affect Brn-3b expression and its downstream targets in cancer cells. Its mechanisms of action might involve modulation of signaling pathways that intersect with Brn-3b's functions, contributing to changes in cell behavior. | ||||||
SF1126 | 936487-67-1 | sc-391584 sc-391584A | 5 mg 10 mg | $719.00 $1331.00 | 7 | |
SF1126 is a small molecule that can potentially inhibit PI3K, which is involved in cell signaling pathways. Since Brn-3b can be influenced by signaling pathways, targeting PI3K with SF1126 might indirectly impact Brn-3b expression and its downstream effects on cell behavior. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1 is a BET bromodomain inhibitor that can potentially disrupt Brn-3b's interaction with chromatin and other protein partners. This interference with Brn-3b's binding could lead to altered gene expression patterns and subsequently impact cell differentiation and proliferation processes. | ||||||
Pimozide | 2062-78-4 | sc-203662 | 100 mg | $102.00 | 3 | |
Pimozide, an antipsychotic drug, has been suggested to influence Brn-3b expression and function. Its mechanisms of action on Brn-3b might involve modulating signaling pathways relevant to neuronal differentiation and survival, potentially impacting the expression of genes controlled by Brn-3b. | ||||||