BRINP2 Inhibitors
BRINP2 Inhibitors encompass a range of chemical compounds that indirectly attenuate the functional activity of BRINP2 via distinct cellular signaling pathways. PD 98059 and U0126, both MEK inhibitors, indirectly diminish the role of BRINP2 in neuronal differentiation by blocking the MAPK/ERK pathway, a crucial signaling cascade for cell cycle progression and differentiation, which BRINP2 is associated with. Similarly, LY 294002 and Wortmannin act as PI3K inhibitors, disrupting the PI3K/Akt signaling pathway, pivotal for neurogenesis and neuronal cell survival, thus indirectly leading to decreased BRINP2 activity. SB 203580 and SP600125, targeting p38 MAPK and JNK respectively, impede inflammatory responses and stress-related apoptosis pathways, potentially reducing BRINP2's role in neuronal differentiation and development.
Furthermore, Rapamycin, an mTOR pathway inhibitor, affects cell growth and proliferation, indirectly influencing BRINP2's function in neuronal differentiation. Y-27632 and Ro 31-8220, as inhibitors of ROCK andPKC, respectively, modify cytoskeleton dynamics and cell survival signaling pathways, thereby indirectly diminishing BRINP2's involvement in neuron formation and structure. NF449 disrupts G-protein-coupled receptor signaling, which is essential for neuronal differentiation processes where BRINP2 is implicated, leading to an indirect reduction in its activity. Gö 6983's inhibition of protein kinase C, and BML-275's blockade of BMP signaling, both contribute to the indirect decrease of BRINP2's functional activity in neurogenesis and neuron differentiation by altering the associated pathways. These inhibitors, through their targeted effects on various signaling pathways, collectively contribute to the attenuation of BRINP2's functional role in neural cell development and differentiation without direct interaction with the protein itself.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
A MEK inhibitor that blocks the MAPK/ERK pathway. Since BRINP2 is implicated in neuronal differentiation and this pathway is critical for cell cycle progression and differentiation, PD 98059 indirectly diminishes BRINP2 function by preventing downstream signaling required for its role in neuronal cells. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor that disrupts the PI3K/Akt signaling pathway. BRINP2, involved in neuronal cell development, is indirectly inhibited as this pathway is crucial for neurogenesis and cell survival, processes where BRINP2 plays a role. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A p38 MAPK inhibitor that impedes inflammatory responses and differentiation pathways. Since BRINP2 is involved in neural differentiation, inhibition of p38 MAPK could indirectly diminish BRINP2's function in neuronal differentiation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Another PI3K inhibitor that leads to the reduction of Akt pathway signaling. This pathway is important for neuronal survival and development, thus wortmannin indirectly decreases BRINP2's functional activity in these processes. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor that affects cell growth and proliferation. BRINP2's role in neuronal differentiation could be diminished indirectly by rapamycin's effect on the mTOR pathway, which is involved in cell growth and neurogenesis. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of the c-Jun N-terminal kinase (JNK), which is involved in stress responses and neuronal apoptosis. BRINP2, which is important for neuronal cell development, may have its function indirectly diminished through the inhibition of JNK pathways. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
A ROCK inhibitor that modulates cytoskeleton dynamics and cell adhesion. Since BRINP2 is implicated in neuronal differentiation, its function may be indirectly diminished by altering the downstream effects of ROCK on neuron formation and structure. | ||||||
NF449 | 627034-85-9 | sc-478179 sc-478179A sc-478179B | 10 mg 25 mg 100 mg | $199.00 $460.00 $1479.00 | 1 | |
A Gs-alpha subunit-specific antagonist that disrupts G-protein-coupled receptor signaling. By inhibiting this pathway, NF449 could indirectly reduce BRINP2 activity in processes such as neuronal differentiation that are dependent on GPCR signaling. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
A protein kinase C inhibitor that can alter signaling pathways involved in cell differentiation and survival. BRINP2's function in neuronal development may be indirectly diminished by Go6983's disruption of PKC-mediated pathways. | ||||||
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $94.00 $348.00 | 69 | |
An inhibitor of BMP signaling which is involved in embryonic development and neurogenesis. BRINP2's role in neuronal differentiation could be indirectly inhibited by blocking BMP pathways with BML-275. | ||||||