BRD2 Activators
The BRD2 Activators constitute a diverse group of chemicals that intricately modulate cellular processes by directly or indirectly influencing the function of the BRD2 protein. One notable member is Resveratrol, a natural polyphenol found in grapes and berries. Resveratrol activates the deacetylase SIRT1, leading to chromatin remodeling and subsequent changes in BRD2 function. Diallyl disulfide, found in garlic, indirectly activates BRD2 by suppressing NF-κB signaling, thereby altering inflammatory gene expression. Curcumin, a polyphenol from turmeric, indirectly activates BRD2 by modulating the Wnt/β-catenin pathway, showcasing its ability to influence intricate signaling networks. Another member, Apigenin, a flavonoid found in parsley, exerts its indirect activation through the PI3K/Akt pathway, demonstrating the interconnectedness of cellular signaling pathways in BRD2 modulation.
These activators also include Ursolic acid, a triterpenoid affecting BRD2 via the Hedgehog pathway, and Quercetin, a flavonoid influencing BRD2 through JNK signaling. Luteolin and Berberine impact BRD2 indirectly by inhibiting NF-κB and activating AMPK pathways, respectively. Genistein modulates BRD2 through the ERK/MAPK pathway, illustrating the specificity of these activators in targeting distinct signaling cascades. Sulforaphane, found in cruciferous vegetables, influences BRD2 via the Nrf2/Keap1 pathway, highlighting the diverse cellular processes affected by BRD2 activators. Celastrol, a triterpenoid from Thunder God Vine, indirectly activates BRD2 through the mTOR pathway, showcasing the multifaceted nature of these activators. In summary, the BRD2 Activators represent a comprehensive array of chemicals that, through specific pathway modulation, intricately influence the function of BRD2 in various cellular processes. These compounds offer valuable tools for understanding the complex regulatory networks involving BRD2.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a natural polyphenol found in various plants, including grapes and berries, is known for its role in activating SIRT1. SIRT1, a deacetylase, modulates BRD2 indirectly by deacetylating histones and regulating chromatin structure. Resveratrol enhances SIRT1 activity, leading to altered chromatin architecture and subsequent transcriptional changes, ultimately influencing BRD2 function in cellular processes. | ||||||
Allyl disulfide | 2179-57-9 | sc-252359 | 25 g | $78.00 | ||
Allyl disulfide has been identified as an indirect activator of BRD2 through its impact on NF-κB signaling. This compound inhibits NF-κB activation, thereby reducing the expression of inflammatory genes. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a natural polyphenol found in turmeric, acts as an indirect activator of BRD2 by modulating the Wnt/β-catenin signaling pathway. It inhibits the pathway by suppressing GSK-3β activity, leading to β-catenin stabilization. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $32.00 $210.00 $720.00 $1128.00 $2302.00 $3066.00 $5106.00 | 22 | |
Apigenin, a flavonoid abundant in parsley and celery, exerts its indirect activation of BRD2 through the PI3K/Akt signaling pathway. By inhibiting PI3K activity, apigenin disrupts the Akt pathway, affecting downstream targets, including BRD2. | ||||||
Carnosic acid | 3650-09-7 | sc-202520 sc-202520A | 10 mg 50 mg | $60.00 $165.00 | 6 | |
Carnosic acid, a phenolic diterpene found in rosemary, acts as an indirect activator of BRD2 by influencing the Notch signaling pathway. Carnosic acid inhibits γ-secretase activity, which is crucial for Notch activation. | ||||||
Ursolic Acid | 77-52-1 | sc-200383 sc-200383A | 50 mg 250 mg | $55.00 $176.00 | 8 | |
Ursolic acid, a natural triterpenoid found in various fruits and herbs, serves as an indirect activator of BRD2 through the modulation of the Hedgehog signaling pathway. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid present in fruits and vegetables, acts as an indirect activator of BRD2 through the inhibition of JNK signaling. By suppressing JNK activity, quercetin disrupts the JNK pathway, influencing downstream targets, including BRD2. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $26.00 $50.00 $99.00 $150.00 $1887.00 | 40 | |
Luteolin, a flavonoid found in various plants, exerts its indirect activation of BRD2 through the inhibition of the NF-κB signaling pathway. By suppressing NF-κB activation, luteolin alters the expression of genes associated with inflammation, including those regulated by BRD2. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine, an isoquinoline alkaloid found in several plants, serves as an indirect activator of BRD2 through the AMP-activated protein kinase (AMPK) pathway. By activating AMPK, berberine influences downstream targets, including BRD2. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, an isoflavone present in soy products, acts as an indirect activator of BRD2 through the modulation of the ERK/MAPK signaling pathway. By inhibiting ERK activation, genistein disrupts the pathway, affecting downstream targets, including BRD2. | ||||||