brachyury 2 Activators
Brachyury 2, a key player in mesodermal differentiation, exhibits protein homodimerization activity and is involved in learning or memory, negative regulation of neuron apoptosis, and positive regulation of nervous system development. Predicted to be located in the cytosol and nucleoplasm, it is expressed in structures such as the central nervous system, sensory organs, skeleton, submandibular gland primordium, and trigeminal nerve. The human orthologs include ARMCX5-GPRASP2. To explore potential activators, we considered various chemicals that impact related pathways. Trichostatin A indirectly activates brachyury 2 by inhibiting HDAC, altering chromatin structure and gene expression. SB431542 indirectly activates brachyury 2 by inhibiting the TGF-β receptor, modulating TGF-β signaling and influencing processes related to mesoderm formation. CHIR99021 indirectly activates brachyury 2 by inhibiting GSK-3, impacting GSK-3-dependent pathways and processes related to mesoderm formation. Vorinostat indirectly activates brachyury 2 through HDAC inhibition, altering chromatin dynamics and transcriptional regulation.
A83-01 indirectly activates brachyury 2 by inhibiting the TGF-β receptor, modulating TGF-β signaling and influencing processes related to mesoderm formation. LDN-193189 indirectly activates brachyury 2 by inhibiting the BMP receptor, modulating BMP signaling and influencing processes related to mesoderm formation. 5-Azacytidine indirectly activates brachyury 2 by inhibiting DNA methyltransferase, altering DNA methylation patterns and gene expression. LDN-214117 indirectly activates brachyury 2 by inhibiting ALK2, modulating BMP signaling and influencing processes related to mesoderm formation. EPZ005687 indirectly activates brachyury 2 by inhibiting EZH2, altering chromatin structure and gene expression. Sodium butyrate indirectly activates brachyury 2 through HDAC inhibition, altering chromatin dynamics and transcriptional regulation. Y-27632 indirectly activates brachyury 2 by inhibiting ROCK, modulating cytoskeletal dynamics and influencing processes related to mesoderm formation. JQ1 indirectly activates brachyury 2 by inhibiting BET bromodomains, altering chromatin dynamics and transcriptional regulation. In summary, these chemicals indirectly influence brachyury 2 through various pathways, modulating chromatin structure, gene expression, cellular processes, and signaling cascades. The activation of brachyury 2 is intricately linked to these processes, contributing to its roles in mesodermal differentiation and the regulation of neural functions. The nuanced interplay between these activators and brachyury 2 highlights the complexity of the molecular mechanisms involved in the control of cell fate determination and developmental processes.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
HDAC inhibitor influencing brachyury 2 indirectly. By inhibiting HDAC, it modulates chromatin structure and gene expression. Brachyury 2, involved in mesodermal differentiation, may be indirectly activated through altered chromatin dynamics and transcriptional regulation. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
TGF-β receptor inhibitor affecting brachyury 2 indirectly. By inhibiting TGF-β receptor, it modulates downstream signaling. Brachyury 2, associated with mesodermal differentiation, may be indirectly activated through altered TGF-β signaling, influencing processes related to mesoderm formation and cell fate determination. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
HDAC inhibitor impacting brachyury 2 indirectly. By inhibiting HDAC, it modulates chromatin structure and gene expression. Brachyury 2, associated with mesodermal differentiation, may be indirectly activated through altered chromatin dynamics and transcriptional regulation. | ||||||
A 83-01 | 909910-43-6 | sc-203791 sc-203791A | 10 mg 50 mg | $198.00 $795.00 | 16 | |
TGF-β receptor inhibitor affecting brachyury 2 indirectly. By inhibiting TGF-β receptor, it modulates downstream signaling. Brachyury 2, involved in mesodermal differentiation, may be indirectly activated through altered TGF-β signaling, influencing processes related to mesoderm formation and cell fate determination. | ||||||
4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline | 1062368-24-4 | sc-476297 | 5 mg | $240.00 | ||
BMP receptor inhibitor impacting brachyury 2 indirectly. By inhibiting BMP receptor, it modulates downstream signaling. Brachyury 2, associated with mesodermal differentiation, may be indirectly activated through altered BMP signaling, influencing processes related to mesoderm formation and cell fate determination. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
DNA methyltransferase inhibitor influencing brachyury 2 indirectly. By inhibiting DNA methyltransferase, it modulates DNA methylation patterns and gene expression. Brachyury 2, involved in mesodermal differentiation, may be indirectly activated through altered DNA methylation patterns and transcriptional regulation. | ||||||
LDN-214117 | 1627503-67-6 | sc-507451 | 5 mg | $165.00 | ||
ALK2 inhibitor affecting brachyury 2 indirectly. By inhibiting ALK2, it modulates BMP signaling. Brachyury 2, associated with mesodermal differentiation, may be indirectly activated through altered BMP signaling, influencing processes related to mesoderm formation and cell fate determination. | ||||||
EPZ005687 | 1396772-26-1 | sc-497734 | 2.5 mg | $380.00 | ||
EZH2 inhibitor impacting brachyury 2 indirectly. By inhibiting EZH2, it modulates chromatin structure and gene expression. Brachyury 2, involved in mesodermal differentiation, may be indirectly activated through altered chromatin dynamics and transcriptional regulation. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 18 | |
HDAC inhibitor influencing brachyury 2 indirectly. By inhibiting HDAC, it modulates chromatin structure and gene expression. Brachyury 2, associated with mesodermal differentiation, may be indirectly activated through altered chromatin dynamics and transcriptional regulation. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
ROCK inhibitor affecting brachyury 2 indirectly. By inhibiting ROCK, it modulates cytoskeletal dynamics. Brachyury 2, involved in mesodermal differentiation, may be indirectly activated through altered cytoskeletal dynamics, influencing processes related to mesoderm formation and cell fate determination. | ||||||