BOC Activators
BOC, or Brother of CDO, is a crucial cell surface receptor implicated in various cellular development processes. It belongs to the immunoglobulin superfamily and is known to interact with the Sonic Hedgehog (Shh) signaling pathway, which is vital for proper embryonic development. The Shh pathway plays a significant role in cell differentiation, growth, and patterning during embryogenesis. BOC's role is particularly emphasized in the context of neuronal development and axon guidance, where it can influence the precise wiring of the nervous system. Its importance extends to myogenic differentiation as well, indicating its broader significance in developmental biology. The regulation of BOC expression is complex and can be influenced by cellular context and environmental cues. Understanding the regulation of BOC expression is not only fundamental to developmental biology but also to cellular biology, as it sheds light on the intricacies of cell signaling and gene expression modulation.
Research into the molecular biology of BOC expression has identified several chemical compounds that can potentially serve as activators. These activators work through various mechanisms to stimulate the expression of BOC at a genetic level. For instance, retinoic acid can trigger nuclear receptor activation, which in turn may upregulate the transcription of developmental genes linked to the Shh pathway. Similarly, forskolin raises cAMP levels, potentially initiating a signaling cascade that leads to enhanced gene transcription. Lithium chloride's ability to inhibit GSK-3 may result in the stabilization of transcription factors that drive the expression of Shh pathway genes. Compounds like Trichostatin A and sodium butyrate modify the chromatin structure, thereby facilitating transcriptional activation of specific genes. Such activators, through different pathways, can influence the chromatin state, signaling cascades, and transcription factor activity, all of which are pivotal in the fine-tuned orchestration of gene expression. The study of these compounds and their interaction with cellular machinery is critical for advancing our knowledge of genetic regulation and the diverse mechanisms cells use to control the expression of important proteins like BOC.
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid serves as an activator of nuclear retinoic acid receptors, which can upregulate the transcription of developmental genes, including those related to the Shh pathway, potentially stimulating BOC expression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin elevates intracellular cAMP levels by activating adenylate cyclase, which can initiate a cascade leading to the transcriptional activation of genes, such as BOC, via cAMP response element-binding (CREB) proteins. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride can inactivate glycogen synthase kinase 3 (GSK-3), leading to stabilization of transcription factors that may enhance the transcription of genes involved in the Shh pathway that includes BOC. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
β-Estradiol binds to estrogen receptors that, once activated, can stimulate the expression of a range of genes, including possibly BOC, by interacting with estrogen-responsive elements in their promoters. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A inhibits histone deacetylases, leading to a more open chromatin structure and facilitating the access of transcription factors to DNA, which may result in increased transcription of certain genes, potentially including BOC. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 18 | |
Sodium butyrate acts as a histone deacetylase inhibitor, promoting a relaxed chromatin state and potentially enhancing the transcriptional upregulation of genes, such as BOC, by allowing transcriptional machinery greater access to DNA. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate has been shown to alter the expression of multiple genes by mechanisms that include the inhibition of DNA methyltransferases, which could lead to the demethylation and transcriptional activation of genes like BOC. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone interacts with glucocorticoid receptors, which upon activation, can bind to glucocorticoid response elements and stimulate the transcription of target genes, which may encompass the gene encoding BOC. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-azacytidine can lead to the hypomethylation of DNA by inhibiting DNA methyltransferases, thereby promoting the transcriptional reactivation of genes that may have been silenced by methylation, including potentially BOC. | ||||||
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $30.00 $115.00 $900.00 | 136 | |
DMSO, as a solvent, may facilitate the cellular uptake of other molecules that can upregulate gene expression and, under certain conditions, has been observed to induce differentiation-associated gene expression, which might include BOC. | ||||||