BMS1 Activators
BMS1, or BMS1 ribosome biogenesis factor, is a highly conserved protein crucial for the biogenesis of ribosomes in eukaryotic cells. It is encoded by the BMS1 gene in humans. Ribosomes are essential cellular structures responsible for protein synthesis, and their assembly involves a complex and highly regulated process where ribosomal RNA (rRNA) and ribosomal proteins are accurately combined.BMS1 plays a pivotal role early in the ribosome assembly pathway. It is particularly involved in the processing of the 35S pre-rRNA, a precursor to the 18S rRNA, which is a component of the small 40S ribosomal subunit. The function of BMS1 is critical in the initial steps of ribosome formation, where it acts as an essential GTPase, a type of enzyme that hydrolyzes GTP (guanosine triphosphate).
The activity of BMS1 is linked with several cofactors and is integral to the formation and stabilization of pre-ribosomal complexes. It interacts with various ribosome assembly factors and is part of a larger network of proteins that coordinate the early stages of ribosome biogenesis. Disruptions in BMS1 function, caused by mutations or dysregulation, can lead to defects in ribosome assembly and function, which can have broad implications given the central role of ribosomes in protein synthesis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
CX-5461 | 1138549-36-6 | sc-507275 | 5 mg | $245.00 | ||
CX-5461 inhibits RNA polymerase I, thereby affecting ribosomal RNA synthesis. This could indirectly influence BMS1 activity by modulating ribosome biogenesis. | ||||||
BMH-21 | 896705-16-1 | sc-507460 | 10 mg | $165.00 | ||
BMH-21 is a small molecule that inhibits RNA polymerase I and induces degradation of RPA194, potentially impacting BMS1-related processes. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D binds to DNA and inhibits RNA polymerase, affecting RNA synthesis. This could indirectly impact BMS1 by altering ribosomal RNA production. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
5-FU is a nucleotide analog that disrupts RNA processing and function, potentially affecting BMS1 activity by impacting ribosome assembly. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide is known to inhibit RNA polymerase II, thereby affecting transcription and potentially influencing ribosomal biogenesis linked to BMS1. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $69.00 $266.00 | 8 | |
Mycophenolic acid inhibits inosine monophosphate dehydrogenase, affecting guanine nucleotide synthesis. This might indirectly impact BMS1 function in ribosome assembly. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor, and since mTOR signaling affects protein synthesis and ribosome biogenesis, it could indirectly modulate BMS1 activity. | ||||||
Homoharringtonine | 26833-87-4 | sc-202652 sc-202652A sc-202652B | 1 mg 5 mg 10 mg | $52.00 $125.00 $182.00 | 11 | |
Homoharringtonine inhibits protein synthesis at the initial stage of elongation, potentially affecting processes related to BMS1. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide inhibits eukaryotic protein synthesis by interfering with the translocation step in ribosome function, potentially influencing BMS1. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin interferes with protein synthesis by inhibiting peptidyl transferase activity, potentially impacting ribosomal biogenesis and BMS1 activity. | ||||||