BMP-3b Activators
BMP-3b activators represent a class of compounds that modulate the activity of Bone Morphogenetic Protein 3b (BMP-3b), also known as GDF-10. BMP-3b is part of the TGF-β superfamily and shares structural similarities with other BMPs, which are involved in a myriad of cellular processes including bone and cartilage development. Although BMP-3b is less studied compared to BMP-3 and other BMPs, it is understood to have unique roles in tissue morphogenesis and repair.
Direct activators of BMP-3b interact with the protein or its associated receptors to enhance its signaling capabilities. This can involve facilitating the binding of BMP-3b to its receptors, promoting receptor dimerization, or stabilizing the active signaling complex. Such direct interactions could lead to increased phosphorylation of downstream Smad proteins, which translocate to the nucleus to effect changes in gene expression. Alternatively, indirect activators might increase the expression levels of BMP-3b, leading to greater protein synthesis and secretion. They could also inhibit natural antagonists of BMP signaling, such as gremlin or follistatin, which might otherwise bind to BMP-3b and sequester it from its receptors. By lifting this inhibition, the indirect activators would potentiate the native activity of BMP-3b.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone is a corticosteroid known to modulate gene expression. By affecting the transcription and subsequent translation of BMP-3b, it can alter the protein's abundance and potential activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases cyclic AMP (cAMP) production, which can activate cAMP-dependent signaling pathways. BMP-3b, involved in bone morphogenetic pathways, may be regulated by these pathways. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid is involved in gene expression regulation. It can affect BMP-3b's transcription, potentially influencing the protein's subsequent translation and functional expression. | ||||||
Indirubin | 479-41-4 | sc-201531 sc-201531A | 5 mg 25 mg | $114.00 $525.00 | 4 | |
Indirubin is a GSK-3β inhibitor. By inhibiting this enzyme, it can modulate Wnt/beta-catenin signaling, a pathway that interacts with BMP signaling, potentially influencing BMP-3b's function. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride inhibits GSK-3β, potentially impacting Wnt/beta-catenin signaling. This pathway can interact with BMP signaling, indirectly affecting BMP-3b. | ||||||
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $66.00 $262.00 | 1 | |
Calcium Chloride participates in calcium signaling regulation, which can influence BMP-3b, considering the role of calcium signaling pathways in cell differentiation and growth. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
TPA activates Protein Kinase C (PKC) that can initiate a cascade of signals potentially interacting with the BMP signaling pathway, thereby influencing BMP-3b. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine inhibits phosphodiesterase, elevating cAMP levels and potentially activating associated pathways that might interact with BMP signaling to impact BMP-3b. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin is a calcium ionophore that can increase intracellular calcium levels, potentially activating calcium-dependent signaling pathways that might interact with the BMP signaling pathway and influence BMP-3b. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin elevates intracellular calcium concentration, potentially activating calcium-dependent signaling pathways that might interact with BMP signaling and influence BMP-3b. | ||||||