Biotin Derivatives

3-(N-Maleimidylpropionyl)biocytin is a specialized biotin derivative known for its maleimide group, which selectively reacts with thiol-containing molecules, enabling precise labeling and conjugation in biochemical studies. This compound exhibits a unique ability to form stable thioether bonds, enhancing its utility in protein engineering. Its hydrophilic properties improve solubility in aqueous environments, facilitating interactions with biomolecules and influencing cellular dynamics.

MTSEA Biotin is a biotin derivative characterized by its unique reactivity with nucleophiles, particularly thiols, due to the presence of a sulfonyl group. This compound facilitates the formation of covalent bonds, allowing for targeted modifications in protein structures. Its distinct hydrophilicity enhances solubility, promoting effective interactions in biological systems. Additionally, MTSEA Biotin's kinetic properties enable rapid conjugation, making it a versatile tool for studying molecular interactions.

N-(+)-Biotinyl-6-aminohexanoic acid is a biotin derivative notable for its ability to engage in specific molecular interactions through its amine and carboxylic acid functional groups. This compound exhibits unique reactivity patterns, allowing for the formation of stable amide bonds with various substrates. Its hydrophobic hexanoic acid chain enhances membrane permeability, while its biotin moiety facilitates strong binding to avidin or streptavidin, enabling precise labeling and tracking in biochemical assays.

N-Biotinyl-N'-(iodoacetyl)-1,6-hexanediamine is a biotin derivative notable for its iodoacetyl group, which facilitates selective labeling and conjugation through nucleophilic attack. The hexanediamine backbone provides flexibility, enhancing molecular interactions with biomolecules. This compound exhibits unique reactivity patterns, allowing for efficient formation of stable thioether bonds with thiol-containing targets, making it a valuable tool for probing protein interactions and dynamics.

DBCO-S-S-PEG3-Biotin is a biotin derivative characterized by its unique dibenzocyclooctyne (DBCO) moiety, which enables efficient strain-promoted alkyne–azide cycloaddition reactions. The presence of a polyethylene glycol (PEG) spacer enhances solubility and biocompatibility, while the biotin component ensures robust interactions with avidin or streptavidin. This compound's distinct structure allows for versatile conjugation strategies, facilitating targeted applications in biochemical research.

Biotin-VAD-FMK is a specialized biotin derivative featuring a unique fluoromethyl ketone moiety that enhances its reactivity with target proteins. This compound exhibits selective covalent binding, allowing for the formation of stable adducts through specific interactions with cysteine residues. Its distinct structural attributes facilitate rapid incorporation into cellular pathways, enabling detailed exploration of protein dynamics and interactions. The compound's unique reactivity profile makes it a valuable tool for dissecting complex biological systems.

Biotin-ring-6,6-d2 is a distinctive biotin derivative characterized by its deuterated ring structure, which enhances its stability and alters its isotopic signature. This modification allows for precise tracking in metabolic studies. The compound exhibits unique binding affinities due to its structural nuances, facilitating specific interactions with avidin and streptavidin. Its kinetic properties enable rapid conjugation reactions, making it an effective probe for studying biomolecular interactions in various experimental contexts.

Biotin LC hydrazide is a distinctive biotin derivative characterized by its hydrazide functional group, which enhances its reactivity towards carbonyl-containing compounds. This compound engages in selective hydrazone formation, allowing for stable conjugation with aldehydes and ketones. Its unique molecular structure promotes efficient labeling and tracking of biomolecules, facilitating insights into metabolic pathways and protein interactions. The compound's reactivity and specificity make it a powerful agent for probing biochemical processes.

N-Biotinylcaproylaminoethyl Methanethiosulfonate is a specialized biotin derivative featuring a methanethiosulfonate group that enables selective thiol-reactive labeling. This compound exhibits unique reactivity with sulfhydryl groups, facilitating the formation of stable thioether bonds. Its distinct molecular architecture allows for targeted conjugation in complex biological systems, enhancing the study of protein interactions and cellular dynamics. The compound's specificity and reactivity contribute to its utility in biochemical research.

2-[Nα-Benzoylbenzoicamido-N6-(6-biotinamidocaproyl)-L-lysinylamido]ethyl Methanethiosulfonate is a sophisticated biotin derivative characterized by its unique ability to engage in selective thiol modifications. The presence of the methanethiosulfonate moiety allows for efficient formation of covalent bonds with thiol groups, promoting stable conjugation. This compound's intricate design facilitates precise labeling and tracking of biomolecules, making it a valuable tool for exploring molecular interactions and pathways in biological research.