Date published: 2026-4-24

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DBCO-S-S-PEG3-Biotin (CAS 1430408-09-5)

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Alternate Names:
Dibenzocyclooctyne-S-S-PEG3-Biotin
CAS Number:
1430408-09-5
Molecular Weight:
869.13
Molecular Formula:
C42H56N6O8S3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

DBCO-S-S-PEG3-Biotin is a versatile reagent employed in copper-free Click Chemistry to attach a biotin group to azide-containing biomolecules. The linker contains a cleavable disulfide bond, allowing for the removal of the biotin label using reducing agents like DTT, BME, and TCEP. PEG linkers, such as PEG3, hold potential in the advancement of antibody drug conjugates (ADCs).


DBCO-S-S-PEG3-Biotin (CAS 1430408-09-5) References

  1. Bioorthogonal labeling cell-surface proteins expressed in pancreatic cancer cells to identify potential diagnostic/therapeutic biomarkers.  |  Haun, RS., et al. 2015. Cancer Biol Ther. 16: 1557-65. PMID: 26176765
  2. 5-Hydroxymethylcytosine (5-hmC) Specific Enrichment.  |  Szulwach, KE., et al. 2012. Bio Protoc. 2: PMID: 27453898
  3. TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells.  |  Verma, N., et al. 2018. Nat Genet. 50: 83-95. PMID: 29203910
  4. Coordinated removal of repressive epigenetic modifications during induced reversal of cell identity.  |  Tran, KA., et al. 2019. EMBO J. 38: e101681. PMID: 31583744
  5. Shiga Toxin Uptake and Sequestration in Extracellular Vesicles Is Mediated by Its B-Subunit.  |  Willysson, A., et al. 2020. Toxins (Basel). 12: PMID: 32664382
  6. A Bisulfite-free Approach for Base-Resolution Analysis of Genomic 5-Carboxylcytosine.  |  Ličytė, J., et al. 2020. Cell Rep. 32: 108155. PMID: 32937122
  7. Distribution and regulatory roles of oxidized 5-methylcytosines in DNA and RNA of the basidiomycete fungi Laccaria bicolor and Coprinopsis cinerea.  |  Ličytė, J., et al. 2022. Open Biol. 12: 210302. PMID: 35232254
  8. Brain Region- and Age-Dependent 5-Hydroxymethylcytosine Activity in the Non-Human Primate.  |  Xu, Y., et al. 2022. Front Aging Neurosci. 14: 934224. PMID: 35912074

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

DBCO-S-S-PEG3-Biotin, 10 mg

sc-497051
10 mg
$391.00

DBCO-S-S-PEG3-Biotin, 25 mg

sc-497051A
25 mg
$681.00

DBCO-S-S-PEG3-Biotin, 100 mg

sc-497051B
100 mg
$2383.00