β-dystroglycan Inhibitors
β-Dystroglycan inhibitors are a specific class of chemical compounds that have garnered significant attention in the field of molecular biology and cellular physiology. These inhibitors are characterized by their ability to selectively target and modulate the function of β-dystroglycan, a transmembrane protein that plays a crucial role in various cellular processes, particularly in maintaining the integrity and stability of muscle fibers and other tissues. β-dystroglycan is an essential component of the dystrophin-glycoprotein complex (DGC), which is responsible for connecting the cytoskeleton of muscle cells to the extracellular matrix. This interaction is vital for the structural support and stability of muscle fibers, making β-dystroglycan an attractive target for research aimed at understanding various neuromuscular disorders.
Chemically, β-dystroglycan inhibitors are designed to interfere with the interactions between β-dystroglycan and its binding partners, such as laminin and dystrophin. By disrupting these molecular interactions, these inhibitors impact the stability and function of the DGC, leading to downstream effects on muscle cell integrity and signaling pathways. The development and study of β-dystroglycan inhibitors have provided valuable insights into the molecular mechanisms underlying muscle dystrophy and related conditions. The role of β-Dystroglycan inhibitors in elucidating the biology of β-dystroglycan and associated cellular processes has been instrumental in advancing our understanding of neuromuscular disorders.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A is an immunosuppressive agent that may inhibit β-dystroglycan expression by altering transcriptional activities or signaling pathways related to muscle differentiation and repair. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is a macrolide compound that can inhibit the mammalian target of rapamycin (mTOR) pathway, potentially reducing β-dystroglycan expression and affecting muscle cell function. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone is a synthetic glucocorticoid that can regulate gene expression. Its potential to inhibit β-dystroglycan expression may be through its anti-inflammatory effects or interactions with glucocorticoid response elements. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid is a short-chain fatty acid with histone deacetylase inhibitory activity. It may alter the chromatin structure and subsequently inhibit the expression of β-dystroglycan. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that can change the chromatin state, potentially leading to the repression of β-dystroglycan expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a cytidine analog that can be incorporated into DNA and RNA, potentially leading to the demethylation of genomic DNA and affecting the expression of β-dystroglycan. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a polyphenol compound found in turmeric. It has various biological activities and may inhibit β-dystroglycan expression by modulating signaling pathways involved in inflammation and cell survival. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenolic compound found in grapes and berries. It may inhibit β-dystroglycan expression through its antioxidant properties or its ability to modulate signaling pathways related to cell growth and survival. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate is a folic acid antagonist. It may inhibit β-dystroglycan expression indirectly by affecting cell proliferation and survival. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea may affect β-dystroglycan expression by interfering with DNA synthesis and repair mechanisms. | ||||||