β-4-Gal-T1 Inhibitors
Chemical inhibitors of β-1,4-galactosyltransferase (β-4-Gal-T1) include a variety of compounds that disrupt different cellular signaling pathways and processes, thereby affecting the enzyme's activity. PD 98059 and U0126 are both inhibitors of MEK, which is upstream of the MAPK/ERK pathway. Inhibition of this kinase by these agents leads to a block in the signaling required for the proper intracellular trafficking and localization of β-4-Gal-T1. Since proper positioning within the cell is crucial for β-4-Gal-T1's function, these inhibitors can cause its mislocalization, leading to a functional decrease in its activity. Similarly, Wortmannin and LY294002 target the PI3K/Akt pathway. By hindering PI3K, these inhibitors can alter downstream signaling that may be important for the regulation of β-4-Gal-T1, which includes its enzymatic activity and possibly the regulation of its expression levels.
Other inhibitors such as SB 203580 and SP600125 target different components of the cellular stress response pathways. SB 203580 inhibits the p38 MAPK, which can alter the phosphorylation state of proteins, including those involved in the regulation of β-4-Gal-T1. On the other hand, SP600125 is an inhibitor of JNK, part of the stress-activated protein kinase signaling pathways; its inhibition can disrupt signaling pathways that modulate the enzyme's activity or stability. Go6983 and GF 109203X are inhibitors of protein kinase C (PKC), and their action can lead to decreased regulation of β-4-Gal-T1 through disrupted phosphorylation, which is critical for the enzyme's function. Genistein, as a tyrosine kinase inhibitor, affects the phosphorylation of proteins involved in a variety of signaling pathways, which can alter the functional dynamics of β-4-Gal-T1. Staurosporine broadly inhibits protein kinases and can therefore have a wide-reaching impact on the regulation of enzyme activity, including that of β-4-Gal-T1. Lastly, Brefeldin A disrupts the Golgi apparatus structure and function, which is essential for the glycosylation process catalyzed by glycosyltransferases such as β-4-Gal-T1, thus inhibiting its activity by preventing proper processing and maturation of glycoproteins.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 is a specific inhibitor of mitogen-activated protein kinase kinase (MEK), which indirectly inhibits β-4-Gal-T1 by impeding the MAPK/ERK pathway that is crucial for the intracellular trafficking and localization of β-4-Gal-T1, potentially leading to its functional inhibition by mislocalization. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB 203580 acts as an inhibitor of p38 MAPK, a kinase that is part of a signaling pathway involved in the regulation of proteins like β-4-Gal-T1. By inhibiting p38 MAPK, SB 203580 can disrupt the functional regulation of β-4-Gal-T1, leading to its inhibition through alteration of its phosphorylation state. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a phosphoinositide 3-kinase (PI3K) inhibitor that can inhibit the PI3K/Akt pathway. The PI3K/Akt pathway is known to regulate a variety of cellular processes, including those that could influence the function of β-4-Gal-T1, thereby leading to its inhibition through downstream signaling effects. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK, which is upstream in the MAPK/ERK pathway. By inhibiting this pathway, U0126 can prevent the proper localization and function of β-4-Gal-T1, as the MAPK/ERK pathway is involved in cellular processes that affect the activity of glycosyltransferases like β-4-Gal-T1. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is an inhibitor of PI3K, and by inhibiting this kinase, it can disrupt the PI3K/Akt signaling pathway. Since this pathway can influence the function of glycosyltransferases like β-4-Gal-T1, Wortmannin can lead to inhibition of β-4-Gal-T1 by affecting its regulation and possibly its enzyme activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which is part of the mTOR signaling pathway that regulates protein synthesis and cellular metabolism. Inhibition of mTOR by Rapamycin may lead to altered glycosylation patterns, potentially inhibiting the enzymatic activity of β-4-Gal-T1 by affecting the substrate availability. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which is involved in stress-activated protein kinase signaling pathways. By inhibiting JNK, SP600125 can indirectly inhibit β-4-Gal-T1 by interfering with signaling pathways that regulate the enzyme's activity or stability. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Go6983 is a pan-protein kinase C (PKC) inhibitor. PKC isoforms are involved in the regulation of various enzymes, including glycosyltransferases. Inhibition of PKC by Go6983 can lead to a decrease in the functional activity of β-4-Gal-T1 through disrupted phosphorylation and regulation of enzyme activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor and can inhibit the phosphorylation of proteins involved in numerous signaling pathways. By doing so, Genistein may inhibit β-4-Gal-T1 by disrupting the signaling pathways that regulate its activity and substrate specificity. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
GF 109203X is another potent inhibitor of protein kinase C (PKC). By inhibiting PKC, it can influence the regulation of β-4-Gal-T1, potentially leading to inhibition of its activity by preventing necessary phosphorylation events that are critical for the enzyme's function. | ||||||