BDH1 Inhibitors
BDH1 inhibitors belong to a class of compounds that specifically target the enzyme 3-hydroxybutyrate dehydrogenase 1 (BDH1), a key player in cellular metabolism. BDH1 is a critical enzyme involved in the ketone body metabolism pathway, which plays a pivotal role in energy homeostasis, particularly during periods of fasting or low-carbohydrate intake. The inhibition of BDH1 is a strategic approach to modulate the metabolic flux within cells, as it directly impacts the conversion of 3-hydroxybutyrate (a ketone body) to acetoacetate in the mitochondria. By impeding this enzymatic step, BDH1 inhibitors disrupt the normal flow of ketone body metabolism, leading to alterations in cellular energy dynamics.
BDH1 inhibitors exhibit a diverse range of chemical scaffolds, each designed to interact with the active site of the BDH1 enzyme, hindering its catalytic activity. The mechanism of action typically involves binding to specific residues within the enzyme's active site, preventing the conversion of 3-hydroxybutyrate to acetoacetate. Researchers and medicinal chemists focus on optimizing the potency and selectivity of these inhibitors to enhance their effectiveness while minimizing off-target effects. The development of BDH1 inhibitors holds promise not only for a deeper understanding of cellular metabolism but also for potential applications in various research contexts related to metabolic disorders and energy regulation within cells.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium oxamate | 565-73-1 | sc-215880 sc-215880B sc-215880C sc-215880D sc-215880A | 5 g 100 g 250 g 1 kg 25 g | $77.00 $469.00 $1106.00 $4111.00 $152.00 | 14 | |
Inhibits lactate dehydrogenase, which can shift cellular metabolism away from lactate production, thereby altering NADH/NAD+ ratios and possibly influencing BDH1 activity indirectly through redox state changes in the cell. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
A glucose analog that inhibits glycolysis, could indirectly affect BDH1 activity by altering the cellular energy state and reducing the availability of NADH, which is a cofactor for BDH1. | ||||||
Dichloroacetic acid | 79-43-6 | sc-214877 sc-214877A | 25 g 100 g | $61.00 $128.00 | 5 | |
Inhibits pyruvate dehydrogenase kinase leading to activation of the pyruvate dehydrogenase complex, which could decrease the availability of substrates for BDH1 by promoting oxidative decarboxylation of pyruvate. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
An agent that primarily inhibits hepatic glucose production, could indirectly affect BDH1 activity by altering cellular energy metabolism and reducing the formation of ketone bodies. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
As a form of vitamin B3, it could influence BDH1 activity by affecting cellular NAD+ levels, which is a cofactor necessary for BDH1 function. | ||||||
Oxaloacetic Acid | 328-42-7 | sc-279934 sc-279934A sc-279934B | 25 g 100 g 1 kg | $306.00 $963.00 $7980.00 | 1 | |
Involved in the TCA cycle, oxaloacetate can sequester acetyl-CoA and potentially reduce the synthesis of ketone bodies, thereby indirectly affecting BDH1 activity. | ||||||
α-Ketoglutaric Acid | 328-50-7 | sc-208504 sc-208504A sc-208504B sc-208504C sc-208504D sc-208504E sc-208504F | 25 g 100 g 250 g 500 g 1 kg 5 kg 16 kg | $33.00 $43.00 $63.00 $110.00 $188.00 $738.00 $2091.00 | 2 | |
A TCA cycle intermediate that could affect cellular redox states and energy metabolism, possibly influencing BDH1 activity by altering the levels of NADH, a cofactor for BDH1. | ||||||
Sodium phenylbutyrate | 1716-12-7 | sc-200652 sc-200652A sc-200652B sc-200652C sc-200652D | 1 g 10 g 100 g 1 kg 10 kg | $77.00 $166.00 $622.00 $5004.00 $32783.00 | 43 | |
A compound that can modulate gene expression and protein acetylation, potentially influencing BDH1 activity through epigenetic mechanisms and post-translational modifications. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Though primarily known as an mTOR inhibitor, rapamycin can have broad effects on cellular metabolism, which might lead to altered BDH1 activity due to shifts in energy homeostasis. | ||||||