Bcl-rambo Inhibitors
Bcl-rambo Inhibitors are a class of compounds that can directly or indirectly decrease the functional activity of Bcl-rambo. These inhibitors primarily act through binding to Bcl-2 family proteins, thus inhibiting their anti-apoptotic activities. This binding can disrupt the functioning of Bcl-rambo, leading to its functional inhibition. ABT-737, Venetoclax, Navitoclax, among others, are BH3 mimetics that bind to Bcl-2 proteins. Their binding inhibits the anti-apoptotic activities of these proteins, which in turn indirectly leads to the functional inhibition of Bcl-rambo. Gossypol, a natural compound, and its derivative Apogossypol, as well as AT-101, another enantiomer of gossypol, also bind to and inhibit Bcl-2 proteins, disrupting their anti-apoptotic activities and leading to the functional inhibition of Bcl-rambo.
Furthermore, Bcl-rambo inhibitors like Obatoclax and Sabutoclax are pan-Bcl-2inhibitors. These compounds bind to multiple Bcl-2 family proteins, including Bcl-rambo, and inhibit their anti-apoptotic activities, leading to the functional inhibition of Bcl-rambo. Other compounds such as TW-37 and HA14-1 work as small molecule inhibitors of Bcl-2 proteins. Their binding to these proteins inhibits the anti-apoptotic activities, indirectly leading to the functional inhibition of Bcl-rambo. Additionally, A-1210477 and S63845 are selective inhibitors of Mcl-1, another member of the Bcl-2 family. Their action can indirectly lead to the functional inhibition of Bcl-rambo, given the complex interplay between the different Bcl-2 family proteins.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
ABT 737 | 852808-04-9 | sc-207242 | 2.5 mg | $204.00 | 54 | |
ABT-737 is a BH3 mimetic that binds to Bcl-2 family proteins, such as Bcl-rambo. When bound, these proteins can no longer inhibit pro-apoptotic proteins, leading to apoptosis and inhibition of Bcl-rambo. | ||||||
Obatoclax Mesylate | 803712-79-0 | sc-364221 sc-364221A | 5 mg 10 mg | $96.00 $141.00 | ||
Obatoclax is a pan-Bcl-2 inhibitor that can bind to multiple Bcl-2 family proteins, including Bcl-rambo. This binding can inhibit the anti-apoptotic activities of these proteins, leading to the functional inhibition of Bcl-rambo. | ||||||
ABT-199 | 1257044-40-8 | sc-472284 sc-472284A sc-472284B sc-472284C sc-472284D | 1 mg 5 mg 10 mg 100 mg 3 g | $118.00 $337.00 $520.00 $832.00 $1632.00 | 10 | |
Navitoclax is a BH3 mimetic that binds to Bcl-2 proteins and inhibits their anti-apoptotic activities. This can indirectly lead to the functional inhibition of Bcl-rambo. | ||||||
Gossypol | 303-45-7 | sc-200501 sc-200501A | 25 mg 100 mg | $116.00 $230.00 | 12 | |
Gossypol is a natural compound that can bind to and inhibit Bcl-2 proteins. This binding can disrupt the anti-apoptotic activities of these proteins, leading to the functional inhibition of Bcl-rambo. | ||||||
Sabutoclax | 1228108-65-3 | sc-472977 | 1 mg | $330.00 | ||
Sabutoclax is a pan-Bcl-2 inhibitor which can bind to multiple Bcl-2 family proteins, including Bcl-rambo. This binding can inhibit the anti-apoptotic activities of these proteins, leading to the functional inhibition of Bcl-rambo. | ||||||
TW-37 | 877877-35-5 | sc-361387 sc-361387A | 10 mg 50 mg | $200.00 $860.00 | 2 | |
TW-37 is a small molecule inhibitor of Bcl-2 proteins. Its binding can inhibit the anti-apoptotic activities of these proteins, leading to the functional inhibition of Bcl-rambo. | ||||||
HA14-1 | 65673-63-4 | sc-205911 sc-205911A | 5 mg 25 mg | $59.00 $209.00 | ||
HA14-1 is a small molecule inhibitor of Bcl-2 proteins. Its binding can inhibit the anti-apoptotic activities of these proteins, leading to the functional inhibition of Bcl-rambo. | ||||||
A-1210477 | 1668553-26-1 | sc-507474 | 5 mg | $195.00 | ||
A-1210477 is a selective Mcl-1 inhibitor that binds to Mcl-1, a Bcl-2 family member. Its action can indirectly lead to the functional inhibition of Bcl-rambo, given the interplay between different Bcl-2 family proteins. | ||||||
S63845 | 1799633-27-4 | sc-507518 | 1 mg | $150.00 | ||
S63845 is a selective Mcl-1 inhibitor that binds to Mcl-1, a Bcl-2 family member. Its action can indirectly lead to the functional inhibition of Bcl-rambo, due to the interplay between different Bcl-2 family proteins. | ||||||