Molecular structure of HA14-1, CAS Number: 65673-63-4
HA14-1 (CAS 65673-63-4)
Alternate Names:
Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate
Application:
HA14-1 is a cell-permeable, nonpeptidic Bcl-2 inhibitor
CAS Number:
65673-63-4
Purity:
>95%
Molecular Weight:
409.23
Molecular Formula:
C17H17BrN2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
HA14-1 is a small molecule that acts as an inhibitor of the anti-apoptotic B-cell lymphoma 2 (Bcl-2) protein. It binds to the Bcl-2 protein and disrupts its function, which is pivotal in the regulation of apoptosis, or programmed cell death. Research involving HA14-1 focuses on the intrinsic pathway of apoptosis, particularly in understanding how the inhibition of Bcl-2 can induce cell death in various cell types. This compound is used in studies aimed at elucidating the mechanisms of action of Bcl-2 and its role in the survival of cancer cells, as well as in the response to cellular stress. HA14-1 is also valuable for probing the balance between pro-apoptotic and anti-apoptotic factors within cells, thereby contributing to the knowledge of cellular responses to DNA damage and other apoptotic stimuli.
HA14-1 (CAS 65673-63-4) References
- Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. | Wang, JL., et al. 2000. Proc Natl Acad Sci U S A. 97: 7124-9. PMID: 10860979
- Apoptotic response to photodynamic therapy versus the Bcl-2 antagonist HA14-1. | Kessel, D., et al. 2002. Photochem Photobiol. 76: 314-9. PMID: 12403453
- The apoptotic effect of HA14-1, a Bcl-2-interacting small molecular compound, requires Bax translocation and is enhanced by PK11195. | Chen, J., et al. 2002. Mol Cancer Ther. 1: 961-7. PMID: 12481420
- HA14-1 selectively induces apoptosis in Bcl-2-overexpressing leukemia/lymphoma cells, and enhances cytarabine-induced cell death. | Lickliter, JD., et al. 2003. Leukemia. 17: 2074-80. PMID: 12931228
- The proteasome inhibitor bortezomib promotes mitochondrial injury and apoptosis induced by the small molecule Bcl-2 inhibitor HA14-1 in multiple myeloma cells. | Pei, XY., et al. 2003. Leukemia. 17: 2036-45. PMID: 14513055
- HA14-1, a small molecule Bcl-2 antagonist, induces apoptosis and modulates action of selected anticancer drugs in follicular lymphoma B cells. | Skommer, J., et al. 2006. Leuk Res. 30: 322-31. PMID: 16213584
- The small organic compound HA14-1 prevents Bcl-2 interaction with Bax to sensitize malignant glioma cells to induction of cell death. | Manero, F., et al. 2006. Cancer Res. 66: 2757-64. PMID: 16510597
- Initiation of apoptosis and autophagy by the Bcl-2 antagonist HA14-1. | Kessel, D. and Reiners, JJ. 2007. Cancer Lett. 249: 294-9. PMID: 17055152
- The small-molecule Bcl-2 inhibitor HA14-1 sensitizes cervical cancer cells, but not normal fibroblasts, to heavy-ion radiation. | Hamada, N., et al. 2008. Radiother Oncol. 89: 227-30. PMID: 18774194
- Small inhibitor of Bcl-2, HA14-1, selectively enhanced the apoptotic effect of cisplatin by modulating Bcl-2 family members in MDA-MB-231 breast cancer cells. | Arisan, ED., et al. 2010. Breast Cancer Res Treat. 119: 271-81. PMID: 19238538
- Mcl-1 is an important determinant of the apoptotic response to the BH3-mimetic molecule HA14-1 in cisplatin-resistant ovarian carcinoma cells. | Simonin, K., et al. 2009. Mol Cancer Ther. 8: 3162-70. PMID: 19887550
- Regulation of HA14-1 mediated oxidative stress, toxic response, and autophagy by curcumin to enhance apoptotic activity in human embryonic kidney cells. | Ranjan, K., et al. 2014. Biofactors. 40: 157-69. PMID: 23559532
- HA14-1 potentiates apoptosis in B-cell cancer cells sensitive to a peptide disrupting IP 3 receptor / Bcl-2 complexes. | Akl, H., et al. 2015. Int J Dev Biol. 59: 391-8. PMID: 26260683
Inhibitor of:
Bcl-2, Bcl-7c, Bcl-G, Bcl-rambo, Bcl-w, Bclp2, BID, BNIP-3, Hrk, NOXA, PUMA, and Tβ-b.Activator of:
Bax, Bcl-2, Bcl-B, and Caspase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HA14-1, 5 mg | sc-205911 | 5 mg | $59.00 | |||
HA14-1, 25 mg | sc-205911A | 25 mg | $209.00 |