BBS4 Inhibitors
BBS4 inhibitors belong to a class of compounds that specifically target the Bardet-Biedl syndrome 4 (BBS4) protein, a critical component of the BBSome complex. The BBSome is a multi-protein assembly involved in intracellular trafficking processes, particularly in the context of primary cilia function. Primary cilia are microtubule-based organelles that protrude from the surface of many cell types and play crucial roles in signal transduction and cellular communication. The BBSome facilitates the transport of signaling receptors and other cargo proteins to and from the ciliary membrane, contributing to the regulation of various signaling pathways.
BBS4, one of the BBSome subunits, serves as a key scaffolding protein in the complex, aiding in the proper assembly and functioning of the BBSome. Inhibitors targeting BBS4 aim to modulate the activity of this protein, thereby influencing the dynamics of the BBSome complex and subsequently impacting ciliary trafficking processes. By specifically blocking the function of BBS4, these inhibitors offer a potential avenue for investigating the intricate regulatory mechanisms governing ciliary transport and cellular signaling.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium can impact glycogen synthase kinase 3 (GSK-3) activity, which is implicated in ciliary stability and intracellular transport. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Sirolimus targets mTOR signaling, which can affect ciliary function and protein synthesis related to ciliary structure. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $94.00 $208.00 | 19 | |
Cyclopamine inhibits the Hedgehog signaling pathway, which plays a role in ciliary processes. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and can indirectly affect ciliary structure and function. | ||||||
Mebendazole | 31431-39-7 | sc-204798 sc-204798A | 5 g 25 g | $46.00 $89.00 | 2 | |
Mebendazole disrupts microtubule synthesis, which is essential for the maintenance of ciliary structure. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine can alter endosomal sorting and trafficking, processes that are important for ciliary function. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $292.00 $822.00 $1540.00 | 1 | |
Metformin can influence AMPK activity, which is linked to ciliary length and function. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid is known to affect gene expression related to ciliary development and function. | ||||||
Niclosamide | 50-65-7 | sc-250564 sc-250564A sc-250564B sc-250564C sc-250564D sc-250564E | 100 mg 1 g 10 g 100 g 1 kg 5 kg | $38.00 $79.00 $188.00 $520.00 $1248.00 $5930.00 | 8 | |
Niclosamide can disrupt Wnt signaling, which has been implicated in ciliary processes and maintenance. | ||||||