Bak Activators
Common Bak Activators include, but are not limited to Fluorouracil CAS 51-21-8, Staurosporine CAS 62996-74-1, Cisplatin CAS 15663-27-1, Resveratrol CAS 501-36-0 and Geldanamycin CAS 30562-34-6.
Bak activators are a category of molecules or processes that specifically target and modulate the activity of the Bak protein. Bak is a key player in the regulation of apoptosis, which is a tightly controlled mechanism of programmed cell death that occurs in multicellular organisms. Apoptosis is essential for the removal of damaged or unwanted cells during development, tissue homeostasis, and immune responses. Bak, along with another protein called Bax, acts as a pro-apoptotic regulator in the intrinsic apoptotic pathway, which is activated by cellular stress, DNA damage, or developmental cues.
The primary role of Bak in apoptosis is to trigger the permeabilization of the mitochondrial outer membrane, leading to the release of pro-apoptotic factors such as cytochrome c from the mitochondria into the cytoplasm. This event ultimately initiates the cascade of molecular events that culminate in cell death. Bak activators, therefore, function by modulating the activity of Bak to either promote or inhibit its pro-apoptotic function. Understanding the regulation of Bak and its activation by specific activators is a critical area of research in cell biology, with implications for various physiological and pathological processes.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
A chemotherapy agent that can increase BAK expression, promoting apoptosis in cancer cells. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
A potent protein kinase inhibitor that induces apoptosis in various cell types, possibly by increasing BAK expression. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
A compound that can induce apoptosis by upregulating pro-apoptotic proteins like BAK. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
A natural compound known to induce apoptosis in various cancer cells, possibly by upregulating BAK. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
An Hsp90 inhibitor that can destabilize anti-apoptotic proteins, potentially increasing BAK activity. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $57.00 $100.00 $250.00 | 129 | |
A kinase inhibitor that can induce BAK-dependent apoptosis in some cell types. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
A proteasome inhibitor that can promote apoptosis by influencing the balance between pro- and anti-apoptotic Bcl-2 family members, including BAK. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
A natural compound that can induce mitochondrial apoptosis by upregulating BAK. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
A topoisomerase II inhibitor that can induce apoptosis through the intrinsic pathway, potentially involving BAK upregulation. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
An anthracycline antibiotic that induces apoptosis in various cell types, potentially by upregulating BAK. | ||||||