AUTS2 Activators
The regulation of AUTS2 (activity-dependent neuroprotector homeobox protein 2) is a complex process that is influenced by various compounds, which can modulate its activity through different signaling pathways. Compounds such as Forskolin, Isoproterenol, Epinephrine, and Dibutyryl-cAMP increase intracellular cyclic AMP (cAMP) levels, either by directly activating adenylate cyclase or by mimicking cAMP's action, leading to the activation of protein kinase A (PKA). PKA then phosphorylates AUTS2, which can enhance its role in neuronal development and synaptic function.
Other compounds affect AUTS2 activity through different mechanisms. For example, PDE inhibitors like Rolipram and IBMX prevent the breakdown of cAMP, indirectly leading to PKA activation and potential AUTS2 enhancement. In contrast, Curcumin and Phorbol 12-myristate 13-acetate (PMA) activate protein kinase C (PKC), offering an alternative pathway for the phosphorylation and modulation of AUTS2 activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates protein kinase A (PKA), which can lead to phosphorylation and activation of AUTS2, as AUTS2 has been shown to be a substrate for PKA. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analog that activates cAMP-dependent pathways by directly stimulating PKA without the need for adenylate cyclase activation. This activation of PKA can enhance AUTS2 phosphorylation and function. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases intracellular cAMP by activating adenylyl cyclase. The subsequent activation of PKA can lead to the phosphorylation and activation of AUTS2. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine binds to beta-adrenergic receptors, stimulating adenylate cyclase and increasing cAMP levels. The activation of PKA downstream can result in the phosphorylation and enhancement of AUTS2 activity. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram inhibits phosphodiesterase-4 (PDE4), preventing the breakdown of cAMP. The resultant increase in cAMP levels can boost PKA activity, which then may phosphorylate and activate AUTS2. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, leading to increased cAMP and cGMP levels in cells. Elevated cAMP can activate PKA, potentially enhancing the phosphorylation and activation of AUTS2. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that activates stress-activated protein kinases (SAPKs). The activation of SAPKs can lead to the phosphorylation of downstream targets, including possible phosphorylation sites on AUTS2, enhancing its activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has been shown to activate protein kinase C (PKC), which can phosphorylate a multitude of proteins. PKC-mediated phosphorylation could potentially enhance the activation of AUTS2. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of PKC. The activation of PKC can lead to the phosphorylation of specific targets, including AUTS2, thereby potentially enhancing its activity. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is an inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation levels of many proteins. By preventing AUTS2 dephosphorylation, Calyculin A could enhance its phosphorylation status and activity. | ||||||