AUNIP Inhibitors
AUNIP inhibitors are an array of chemical compounds that exert their influence by destabilizing or altering various cellular processes and pathways that AUNIP is inherently involved in, particularly those associated with cell cycle regulation and centrosome cohesion. For instance, Staurosporine and Roscovitine, both kinase inhibitors, lead to a reduction in the phosphorylation levels of proteins within cellular pathways that AUNIP is a part of, thereby indirectly reducing AUNIP's functional activity. Similarly, Thapsigargin raises cytosolic calcium levels, potentially disrupting calcium-dependent regulatory mechanisms that could influence AUNIP's function. CDK inhibitors like PD 0332991 and Purvalanol B also play a role by stalling cell cycle progression, which is tightly linked to AUNIP's regulatory role in centrosome cohesion and function.
Additional inhibitors include ZM-447439 and Alisertib, which specifically target Aurora kinases, thereby affecting chromosome alignment and segregation-a process where AUNIP's role is critical due to its association with centrosome integrity. Furthermore, inhibitors such as BI6727, S-Trityl-L-cysteine, and Monastrol disrupt mitotic progression and spindle assembly by targeting proteins like Plk1 and the mitotic kinesin Eg5, thereby indirectly impacting AUNIP's function related to the mitotic spindle assembly. Mitoxantrone and Nocodazole, by interfering with topoisomerase II and microtubule dynamics, respectively, contribute to the indirect inhibition of AUNIP by affecting DNA replication and cell division processes that are essential for the proper functioning of AUNIP in the cell cycle. Collectively, these inhibitors showcase the intricate network of pathways that AUNIP is involved in, and through these diverse mechanisms, they diminish the functional activity of AUNIP without directly altering its expression or activity.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
A potent kinase inhibitor that by inhibiting a broad spectrum of kinases can reduce the phosphorylation levels of various proteins, indirectly diminishing AUNIP's function in cell cycle regulation by altering the phosphorylation state of proteins that interact with or regulate AUNIP. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
A cyclin-dependent kinase inhibitor which impedes cell cycle progression. As AUNIP is implicated in centrosome cohesion, this inhibition can detrimentally affect AUNIP's role in cell division by disrupting the necessary kinase activity for centrosome function. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
A non-competitive inhibitor of the endoplasmic reticulum Ca2+ ATPase, leading to a sustained increase in cytosolic calcium levels. Elevated calcium can indirectly diminish AUNIP's function by perturbing the calcium-dependent cell cycle regulatory mechanisms in which AUNIP might be involved. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $321.00 | ||
A selective inhibitor of CDK4/6, thereby stalling the cell cycle. By inhibiting these kinases, the chemical indirectly affects AUNIP's function related to cell cycle progression and centrosome cohesion, by altering the activity of proteins that control these processes. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
An Aurora kinase inhibitor that impacts chromosome alignment and segregation. As AUNIP is associated with centrosome cohesion, inhibition of Aurora kinases could disrupt centrosome-dependent processes, thereby indirectly affecting AUNIP's functional role in the cell cycle. | ||||||
BI6727 | 755038-65-4 | sc-364432 sc-364432A sc-364432B sc-364432C sc-364432D | 5 mg 50 mg 100 mg 500 mg 1 g | $150.00 $1050.00 $1665.00 $3329.00 $4382.00 | 1 | |
A Polo-like kinase 1 (Plk1) inhibitor, crucial for mitotic progression. Inhibition of Plk1 can lead to cell cycle arrest, indirectly diminishing AUNIP's role in the cell cycle, particularly in mitosis where centrosome integrity is crucial. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $32.00 $66.00 | 6 | |
An inhibitor of the mitotic kinesin Eg5, which is essential for spindle bipolarity. By disturbing spindle formation, this compound indirectly diminishes AUNIP's role in cell division as AUNIP is associated with centrosome cohesion and may influence spindle dynamics. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Another Eg5 kinesin inhibitor that impairs spindle apparatus assembly. This affects AUNIP indirectly by disrupting the proper formation of the mitotic spindle, a process AUNIP is potentially involved in through its role in centrosome cohesion. | ||||||
MLN8237 | 1028486-01-2 | sc-394162 | 5 mg | $220.00 | ||
An Aurora A kinase inhibitor, which affects mitotic entry and spindle assembly. Alisertib's inhibition of Aurora A kinase may indirectly affect AUNIP's role in centrosome integrity and spindle dynamics during cell division. | ||||||
Mitoxantrone | 65271-80-9 | sc-207888 | 100 mg | $285.00 | 8 | |
A topoisomerase II inhibitor that disrupts DNA replication and cell division. This action can indirectly affect AUNIP by changing the dynamics of DNA replication stress response, in which AUNIP might play a role. | ||||||