AU019823 Activators
AU019823 Activators encompass a diverse set of chemical compounds that engage distinct signaling pathways to enhance the functional activity of AU019823. The activation landscape includes adenylyl cyclase stimulators, such as Forskolin and Isoproterenol, which amplify intracellular cAMP levels, thereby activating protein kinase A (PKA). If AU019823 serves as a substrate for PKA, its activity would be enhanced through phosphorylation by this kinase. SimilarlyI apologize for the error in the previous submission. AU019823 Activators are a collection of chemical compounds that indirectly enhance the functional activity of AU019823 by modulating various signaling pathways and cellular processes. Forskolin and Isoproterenol, through their activation of adenylyl cyclase, increase intracellular cyclic AMP levels, which in turn activates protein kinase A (PKA). PKA, upon activation, phosphorylates various substrates, including potentially AU019823 if it is a PKA substrate, resulting in enhanced activity.
Phorbol 12-myristate 13-acetate (PMA) serves as an activator of protein kinase C (PKC), another kinase that phosphorylates a wide array of cellular targets. If AU019823 is among these targets, PMA would promote its activity. Ionomycin, by increasing intracellular calcium concentrations, activates calcium-dependent proteins which could include AU019823, leading to its upregulated activity. Similarly, Thapsigargin, by inhibiting the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), indirectly causes an increase in cytosolic calcium that might enhance AU019823 activity if it is calcium-responsive. The functional profile of AU019823 is further influenced by the modulation of protein kinases and phosphatases, as exemplified by Epigallocatechin gallate (EGCG) and the phosphoinositide 3-kinases (PI3K) inhibitors LY294002 and Wortmannin. EGCG inhibits competitive protein kinases, potentially upregulating pathways where AU019823 is involved. LY294002 and Wortmannin, through inhibition of the PI3K/AKT pathway, might relieve inhibitory control over AU019823, thereby enhancing its activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to increased levels of cyclic AMP (cAMP) in cells. Elevated cAMP activates protein kinase A (PKA), which can then phosphorylate target proteins. If AU019823 is a PKA substrate, phosphorylation by PKA would enhance the activity of AU019823. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). Activation of PKC leads to the phosphorylation of target proteins that are involved in various cellular processes. If AU019823 is a substrate for PKC, PMA-induced PKC activation would enhance its activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. This elevation in calcium can activate calcium-dependent proteins and pathways. If AU019823 activity is calcium-dependent, ionomycin would therefore enhance its functional activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a polyphenol that can inhibit various protein kinases. By inhibiting competing kinases, EGCG may enhance signaling pathways that are positively regulated by AU019823, if it is part of such pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of phosphoinositide 3-kinases (PI3K). Inhibition of PI3K can alter signaling pathways downstream, potentially relieving negative regulation on AU019823 if it is negatively regulated by PI3K/AKT pathway. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P is a bioactive lipid that activates sphingosine-1-phosphate receptors, leading to diverse cellular responses. If AU019823 is involved in such pathways, S1P could enhance its activity through receptor-mediated signaling. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that also activates stress-activated protein kinases (SAPKs). If AU019823 functions downstream of SAPKs, anisomycin-induced SAPK activation could enhance AU019823 activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK, a kinase involved in the MAPK/ERK pathway. By inhibiting MEK, U0126 could shunt signaling through alternative pathways that may activate AU019823 if it is a part of these alternative pathways. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to increased cytosolic calcium levels. This can activate calcium-dependent proteins, potentially enhancing the activity of AU019823 if it is calcium-dependent. | ||||||
Calcium dibutyryladenosine cyclophosphate | 362-74-3 | sc-482205 | 25 mg | $147.00 | ||
db-cAMP is a cAMP analog that penetrates cell membranes and activates PKA. This can lead to the phosphorylation of PKA substrates, potentially including AU019823, thereby enhancing its activity. | ||||||