ATXN2L Activators
ATXN2L, a member of the ataxin family, plays a crucial role in various cellular processes, including RNA metabolism, stress response, and apoptosis regulation. Functionally, ATXN2L is involved in the modulation of gene expression, protein translation, and cellular signaling pathways, contributing to cellular homeostasis and adaptation to environmental changes. Activation of ATXN2L is mediated by various chemical activators, such as forskolin, resveratrol, and A769662, which target key cellular signaling pathways involved in its regulation. These activators modulate ATXN2L activity through mechanisms such as phosphorylation, deacetylation, and downstream signaling pathway activation, leading to enhanced cellular functions and metabolic regulation.
The activation of ATXN2L is orchestrated by a complex interplay of signaling cascades and molecular mechanisms that converge to regulate its activity and function. Chemical activators, including natural compounds like resveratrol and synthetic agents like A769662, exert their effects by targeting specific cellular pathways such as AMPK and SIRT1, which directly or indirectly influence ATXN2L activation. Through modulation of these pathways, ATXN2L is phosphorylated, deacetylated, and activated, promoting its involvement in cellular processes related to metabolism, stress response, and cellular homeostasis.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylate cyclase, leading to increased cAMP levels, which activate protein kinase A (PKA), subsequently activating ATXN2L. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Stimulates SIRT1, a NAD+-dependent histone deacetylase, which modulates ATXN2L expression and activity through deacetylation and activation. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $180.00 $726.00 $1055.00 $3350.00 $5200.00 | 23 | |
Activates AMP-activated protein kinase (AMPK), which phosphorylates and activates ATXN2L, promoting its functional activation in cellular processes. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Inhibits tyrosine kinases, leading to activation of downstream signaling pathways that enhance ATXN2L function and cellular activities. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Activates AMPK, which in turn activates ATXN2L through phosphorylation, promoting its involvement in various cellular processes and functions. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Activates AMPK, leading to phosphorylation and activation of ATXN2L, thereby enhancing its role in cellular metabolism and energy homeostasis. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Modulates multiple signaling pathways, including AMPK and SIRT1, indirectly activating ATXN2L and promoting its involvement in cellular functions. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Activates AMPK and SIRT1, leading to the activation of ATXN2L and modulation of its functions in cellular processes and metabolic regulation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Activates AMPK and SIRT1, promoting the activation and involvement of ATXN2L in various cellular processes and metabolic regulation. | ||||||
Icariin | 489-32-7 | sc-279198 sc-279198A sc-279198B | 1 g 5 g 10 g | $142.00 $413.00 $814.00 | ||
Activates AMPK and SIRT1, facilitating the activation of ATXN2L and enhancing its functions in cellular metabolism and energy regulation. | ||||||