ATP9BL2 Activators

ATP9BL2, also known as ATPase Phospholipid Transporting 9B Like 2, is a protein that is believed to belong to the P4-ATPase subfamily of phospholipid-transporting ATPases. These proteins are integral membrane proteins that are specialized in flipping phospholipids from the outer to the inner leaflet of cellular membranes, a process critical to maintaining the asymmetric distribution of phospholipids in the lipid bilayer.

The specific function of ATP9BL2 is not as well-characterized as other members of the P4-ATPase family, but by analogy, it is likely involved in cellular processes that depend on membrane lipid composition and asymmetry. Such processes include vesicle formation, cell division, and the maintenance of membrane integrity. The translocation of specific phospholipids to the cytoplasmic side of the bilayer by ATP9BL2 could be essential for creating membrane curvature, which facilitates vesicle budding and fusion events necessary for intracellular trafficking.ATP9BL2 may possess a structure typical of P-type ATPases, with a catalytic domain that binds and hydrolyzes ATP, transmembrane domains that form the substrate translocation pathway, and regulatory regions that modulate the enzyme's activity. Phosphorylation and dephosphorylation events are central to the transport mechanism, involving the formation of a phosphorylated enzyme intermediate.