Date published: 2025-10-7

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ATP5 Inhibitors

ATP5 Inhibitors are a specific class of compounds that target and inhibit the ATP synthase enzyme, particularly the ATP5 subunit. ATP synthase is a crucial enzyme in the mitochondrial inner membrane, responsible for the synthesis of adenosine triphosphate (ATP), which is the primary energy carrier in cells. The ATP5 subunit plays an integral role in the function of ATP synthase by facilitating the rotary mechanism that drives the production of ATP from adenosine diphosphate (ADP) and inorganic phosphate. Inhibitors of ATP5 are instrumental in research that aims to understand the mechanisms of energy production and its regulation within cells. Research into ATP5 Inhibitors is particularly valuable for exploring the intricacies of mitochondrial function and bioenergetics. By inhibiting ATP5, scientists can disrupt the normal production of ATP, thereby allowing them to study the consequences of reduced cellular energy levels on various physiological processes. This can reveal insights into how cells respond to energy stress, how they manage energy resources, and how mitochondrial function is linked to broader cellular activities. Additionally, ATP5 Inhibitors can be used to investigate the role of mitochondrial ATP production in different tissues, contributing to a deeper understanding of tissue-specific energy metabolism. These inhibitors also serve as tools for studying the interplay between mitochondrial function and other cellular pathways, shedding light on the complex networks that maintain cellular homeostasis. Overall, ATP5 Inhibitors are indispensable in the study of mitochondrial bioenergetics and the broader implications of energy production in cellular biology.

Items 11 to 17 of 17 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Bafilomycin A1

88899-55-2sc-201550
sc-201550A
sc-201550B
sc-201550C
100 µg
1 mg
5 mg
10 mg
$96.00
$250.00
$750.00
$1428.00
280
(6)

Bafilomycin A1 inhibits V-ATPases, which could indirectly affect ATP5 by altering proton gradients essential for ATP synthase function.

Isoapoptolidin

476647-30-0sc-202187
100 µg
$350.00
(0)

Isoapoptolidin functions as an ATP5 by selectively binding to the F1 sector of ATP synthase, leading to a disruption in ATP production. Its unique stereochemistry facilitates specific interactions with key amino acid residues, altering the enzyme's catalytic activity. The compound exhibits notable reaction kinetics, characterized by rapid association and slower dissociation rates, which enhances its inhibitory effect on ATP synthesis and impacts cellular energy dynamics.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$60.00
$185.00
$365.00
64
(2)

Resveratrol impacts mitochondrial function and could indirectly inhibit ATP5 by altering mitochondrial dynamics and bioenergetics.

Rotenone

83-79-4sc-203242
sc-203242A
1 g
5 g
$89.00
$254.00
41
(1)

Rotenone inhibits mitochondrial electron transport, which might indirectly affect ATP5 activity by reducing mitochondrial membrane potential.

Antimycin A

1397-94-0sc-202467
sc-202467A
sc-202467B
sc-202467C
5 mg
10 mg
1 g
3 g
$54.00
$62.00
$1642.00
$4600.00
51
(1)

Antimycin A inhibits the electron transport chain, potentially affecting ATP5 by decreasing proton motive force for ATP synthesis.

Sodium azide

26628-22-8sc-208393
sc-208393B
sc-208393C
sc-208393D
sc-208393A
25 g
250 g
1 kg
2.5 kg
100 g
$42.00
$152.00
$385.00
$845.00
$88.00
8
(2)

Sodium azide inhibits mitochondrial electron transport, which could indirectly reduce ATP5's activity in ATP production.

FCCP

370-86-5sc-203578
sc-203578A
10 mg
50 mg
$92.00
$348.00
46
(1)

FCCP uncouples oxidative phosphorylation, potentially affecting ATP5 by disrupting the proton gradient necessary for its activity.