Atonal Inhibitors
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
Inhibits the Hedgehog (Hh) signaling pathway by binding to and inhibiting the Smoothened (SMO) protein, which is crucial for the activation of the Hh pathway, leading to the suppression of downstream gene transcription that would otherwise promote atonal expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Inhibits phosphoinositide 3-kinases (PI3K), leading to reduced Akt phosphorylation and activity. This inhibition may downregulate cell survival and proliferation signals, which can decrease the cellular contexts in which atonal might be upregulated or necessary for function. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
Inhibits MEK1/2, leading to a blockade of the MAPK/ERK signaling pathway. Since MAPK/ERK signaling can regulate a variety of transcription factors and cellular processes that may involve atonal, inhibition by U0126 can suppress the functional context where atonal is active. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $99.00 $335.00 $836.00 $2099.00 | 47 | |
Gamma-secretase inhibitor that prevents the cleavage of many substrates, including Notch receptors. Given that Notch signaling can regulate neurogenesis and the expression of genes like atonal, DAPT can indirectly inhibit the atonal protein's functional role by altering cell fate determination. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
Inhibitor of the TGF-beta receptor ALK5, which leads to the inhibition of the TGF-beta signaling pathway. TGF-beta signaling can influence the development and differentiation of various cell types, potentially including those where atonal is active, thereby inhibiting its functional role. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
MEK inhibitor that blocks the MAPK/ERK pathway. By inhibiting this pathway, PD98059 can reduce the activity of transcription factors and processes that would otherwise support the functional environment for atonal's role in cell differentiation. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
Inhibits the JNK signaling pathway, which is involved in controlling a number of cellular processes, including cell fate decisions. Inhibition of JNK signaling by SP600125 can thus indirectly inhibit the cellular processes that depend on atonal. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Inhibits the Rho-associated protein kinase (ROCK), which can regulate actin cytoskeleton dynamics. By inhibiting ROCK, Y-27632 can indirectly inhibit cellular processes that might be necessary for atonal's role in cell morphology and differentiation. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $35.00 $115.00 $515.00 | 26 | |
Inhibits the Wnt pathway by stabilizing Axin and promoting beta-catenin degradation. Since Wnt signaling is crucial for various aspects of cell fate determination and differentiation, inhibition by XAV-939 can indirectly reduce the functional context in which atonal operates. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
PI3K inhibitor that prevents the formation of PIP3, thus inhibiting AKT phosphorylation and signaling. Reduced AKT activity by Wortmannin can diminish survival and proliferation signaling, indirectly inhibiting the cellular environment where atonal is functional. | ||||||