ATF-6α Inhibitors
Common ATF-6α Inhibitors include, but are not limited to Tunicamycin CAS 11089-65-9, Thapsigargin CAS 67526-95-8, Brefeldin A CAS 20350-15-6, Salubrinal CAS 405060-95-9 and 4-Phenylbutyric acid CAS 1821-12-1.
Activating transcription factor 6 alpha (ATF-6α) is a crucial component of the endoplasmic reticulum (ER) stress response system, commonly known as the unfolded protein response (UPR). The UPR is a cellular defense mechanism activated when the ER, a cellular organelle responsible for protein synthesis and folding, becomes overwhelmed with misfolded or unfolded proteins. ATF-6α is one of the three primary ER stress sensors, alongside IRE1 and PERK. Under non-stress conditions, ATF-6α resides in the ER membrane in an inactive form. However, upon sensing ER stress, ATF-6α translocates to the Golgi apparatus, where it undergoes proteolytic cleavage. This cleavage releases its cytosolic fragment, which then migrates to the nucleus and acts as a transcription factor, activating genes that help restore ER homeostasis.
ATF-6α inhibitors are chemical compounds designed to modulate the activity of ATF-6α and, by extension, influence the UPR. These inhibitors typically function by hindering the activation, cleavage, or nuclear translocation of ATF-6α. By inhibiting ATF-6α's actions, these compounds can effectively dampen or shut down one arm of the UPR, leading to a modified cellular response to ER stress.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
A known inducer of ER stress, prolonged exposure might lead to a negative feedback mechanism down-regulating ATF-6α. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
By causing ER calcium depletion, thapsigargin induces ER stress, which might indirectly lead to altered ATF-6α expression. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
This compound disrupts Golgi apparatus, potentially influencing ATF-6α processing and expression. | ||||||
Eeyarestatin I | 412960-54-4 | sc-358130B sc-358130 sc-358130A sc-358130C sc-358130D sc-358130E | 5 mg 10 mg 25 mg 50 mg 100 mg 500 mg | $114.00 $203.00 $354.00 $697.00 $1363.00 $5836.00 | 12 | |
An ER-associated degradation inhibitor, its impact on ER homeostasis might influence ATF-6α levels. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
A proteasome inhibitor, MG-132 can impact various cellular pathways including the UPR, possibly affecting ATF-6α. | ||||||
Kifunensine | 109944-15-2 | sc-201364 sc-201364A sc-201364B sc-201364C | 1 mg 5 mg 10 mg 100 mg | $135.00 $540.00 $1025.00 $6248.00 | 25 | |
By inhibiting ER-associated degradation, kifunensine's impact on ER stress might alter ATF-6α expression. | ||||||
DBeQ | 177355-84-9 | sc-499943 | 10 mg | $330.00 | 1 | |
As a VCP/p97 inhibitor, it affects ER-associated degradation and could influence ATF-6α levels. | ||||||
STF 083010 | 307543-71-1 | sc-474562 sc-474562A sc-474562B sc-474562C sc-474562D | 5 mg 10 mg 50 mg 100 mg 200 mg | $130.00 $184.00 $408.00 $714.00 $1236.00 | 3 | |
Specifically inhibits IRE1α RNase activity in the UPR, which might indirectly influence ATF-6α levels. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
By modulating calcium channels in the ER, 2-APB can influence ER stress and thereby potentially ATF-6α expression. | ||||||